BubR1 kinase: protection against aneuploidy and premature aging

•BubR1 exhibits multiple roles in the mitotic checkpoint and beyond. •BubR1 complexes: new pharmacological targets for anticancer therapy? •BubR1 contributes to preventing premature aging. The multidomain protein kinase BubR1 is a central component of the mitotic spindle assembly checkpoint (SAC), an essential self-monitoring system of the eukaryotic cell cycle that ensures the high fidelity of chromosome segregation by delaying the onset of...