Longitudinal diffusion tensor imaging in frontotemporal dementia

Objective Novel biomarkers for monitoring progression in neurodegenerative conditions are needed. Measurement of microstructural changes in white matter (WM) using diffusion tensor imaging (DTI) may be a useful outcome measure. Here we report trajectories of WM change using serial DTI in a cohort with behavioral variant frontotemporal dementia (bvFTD). Methods Twenty‐three patients with bvFTD (12 having genetic mutations), and 18 age‐matched...