Cortical gyrification reductions and subcortical atrophy in Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and non-motor symptoms. Previous morphometric studies of PD were mainly conducted by measuring gray matter volume and cortical thickness, and little attention has been paid to the morphology of the cortical surface.Using a surface-based local gyrification index (lGI), this study compared the cortical gyrification patterns of 37 PD patients and 34 matched healthy...