Comparison of the three-dimensional organization of sperm and fibroblast genomes using the Hi-C approach

The three-dimensional organization of the genome is tightly connected to its biological function. The Hi-C approach was recently introduced as a method that can be used to identify higher-order chromatin interactions genome-wide. The aim of this study was to determine genome-wide chromatin interaction frequencies using the Hi-C approach in mouse sperm cells and embryonic fibroblasts.The obtained data demonstrate that the three-dimensional genome...