Oxidative stress and myocardial injury in the diabetic heart.

Published on Jan 1, 2013in The Journal of Pathology5.94
· DOI :10.1002/path.4113
David M. Ansley20
Estimated H-index: 20
(UBC: University of British Columbia),
Baohua Wang6
Estimated H-index: 6
(UBC: University of British Columbia)
Reactive oxygen or nitrogen species play an integral role in both myocardial injury and repair. This dichotomy is differentiated at the level of species type, amount, duration of free radical generated. Homeostatic mechanisms designed to prevent free radical generation in the first instance, scavenge, or enzymatically convert them to less toxic forms and water, play crucial roles in maintenance of cellular structure and function. The outcome between functional recovery and dysfunction is dependent upon the inherent ability of these homeostatic antioxidant defenses to withstand acute free radical generation, in the order of seconds to minutes. Alternatively, pre-existent antioxidant capacity (from intracellular and extracellular sources) may regulate the degree of free radical generation. This converts reactive oxygen and nitrogen species to the role of second messenger involved in cell signalling. The adaptive capacity of the cell is altered by the balance between death or survival signal converging at the level of the mitochondria, with distinct pathophysiologic consequences that extends the period of injury from hours to days and weeks. Hyperglycemia, hyperlipidemia, and insulin resistance enhance oxidative stress in diabetic myocardium that cannot adapt to ischemia reperfusion. Altered glucose flux, mitochondrial derangements and nitric oxide synthase uncoupling in the presence of decreased antioxidant defense and impaired prosurvival cell signalling may render the diabetic myocardium more vulnerable to injury, remodelling and heart failure.
  • References (121)
  • Citations (111)
#1Alex F. Chen (University of Pittsburgh)H-Index: 30
#2Dan-Dan Chen (University of Pittsburgh)H-Index: 10
Last.Ismail Laher (UBC: University of British Columbia)H-Index: 44
view all 7 authors...
#1Megumi Eguchi (Institut Pasteur Korea)H-Index: 8
#2Young Hwa Kim (SNU: Seoul National University)H-Index: 4
Last.Gary Sweeney (Institut Pasteur Korea)H-Index: 17
view all 8 authors...
#1Koen Raedschelders (UBC: University of British Columbia)H-Index: 8
#2David M. Ansley (UBC: University of British Columbia)H-Index: 20
Last.David D. Y. Chen (UBC: University of British Columbia)H-Index: 32
view all 3 authors...
#1Rita Maalouf (Notre Dame University – Louaize)H-Index: 5
#2Assaad A. Eid (AUB: American University of Beirut)H-Index: 16
Last.Hanna E. Abboud (University of Texas Health Science Center at San Antonio)H-Index: 61
view all 7 authors...
#1Pitchai Balakumar (Chicago, Rock Island and Pacific Railroad)H-Index: 8
#2Nidhi Krishan Sharma (Chicago, Rock Island and Pacific Railroad)H-Index: 2
#1Hannah J. Whittington (UCL: University College London)H-Index: 4
#2Girish Babu (UCL: University College London)H-Index: 7
Last.Derek J. Hausenloy (UCL: University College London)H-Index: 71
view all 5 authors...
#1Franco Folli (University of Texas Health Science Center at San Antonio)H-Index: 56
#2Domenico Corradi (University of Parma)H-Index: 32
Last.Giovanna Muscogiuri (UCSC: Catholic University of the Sacred Heart)H-Index: 21
view all 8 authors...
Cited By111
#1Shengzhong Liu (Sichuan University)H-Index: 1
#2Ying He (Academy of Medical Sciences, United Kingdom)H-Index: 1
Last.Yingqiang Guo (Sichuan University)H-Index: 6
view all 7 authors...
#1Tao Jiang (HMU: Harbin Medical University)H-Index: 1
#2Yan-hong Liu (HMU: Harbin Medical University)H-Index: 1
Last.Xiaoguang Cui (HMU: Harbin Medical University)H-Index: 3
view all 8 authors...
View next paperOxidative Stress and Diabetic Complications