4-Hydroxynonenal Induces Mitochondrial-Mediated Apoptosis and Oxidative Stress in SH-SY5Y Human Neuronal Cells

: Excessive and sustained increases in oxidative stress and apoptosis have been implicated in the pathogenesis of many diseases. In this study, we demonstrated that 4‐hydroxynonenal (4‐HNE), a product of lipid peroxidation in a range of concentration (0.1–50 μM) showed cytotoxic effects on SH‐SY5Y cell culture at a concentration >5 μM at 4 hr of exposure. 4‐HNE dose dependently decreased cell viability and significantly promoted reactive...