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Cytotoxic activity of bis-[di-n-butyl(4-aminosalicylato)tin] oxide, NSC: 628561, bis-[diphenyl(4-aminosalicylato)tin] oxide, NSC: 628562, and some related compounds, against a series of human tumour cell lines.

Published on Jan 1, 1992in Anticancer Research 1.94
Marcel Gielen34
Estimated H-index: 34
,
Rudolph Willem38
Estimated H-index: 38
Abstract
Bis[di-n-butyl (4-aminosalicylato)tin] oxide [NSC: 628561] (compound 1), bis [diphenyl(4-aminosalicylato)tin] oxide [NSC: 628562] (compound 2), and six other analogous compounds of the type [n-Bu2 (XYZ-C6H2COO)Sn]2O (compounds 3 to 8), were tested in vitro at the National Cancer Institute, Bethesda, Maryland, USA, for cytotoxic activity against a series of human cell lines. Compounds 1, 6 and 8 score globally satisfactorily since four of the five relevant sensitivity or selectivity parameters, DGI50, DTGI or DLC50, DH and MGDH, are statistically significant. Compounds 3 and 7 are less satisfactory because only three such parameters are statistically significant. For compound 2, only two of the parameters are significant.
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Published on Dec 28, 2015
Xiao Xiao1
Estimated H-index: 1
,
wenliang Li1
Estimated H-index: 1
+ 1 AuthorsWenxiu Zhao1
Estimated H-index: 1
An overview is given of the research on organotin carboxylates, including architecture formation, molecular and supramolecular architectural styles, spectra studies and antitumour activities. The development of antitumour organotin carboxylates is discussed for selected classes. They show high activities but the therapeutic potential is deeply hampered by their solubility in water and side effects. Further research to develop novel antitumour organotin carboxylates and effective methods to achie...
2 Citations Source Cite
Published on Jan 1, 2015in Dalton Transactions 4.05
Farooq Ali Shah5
Estimated H-index: 5
(QAU: Quaid-i-Azam University),
Shaista Sabir3
Estimated H-index: 3
(Allama Iqbal Open University)
+ 3 AuthorsCorrado Rizzoli32
Estimated H-index: 32
(University of Parma)
Three new organotin(IV) carboxylates (1–3) of 3,5-dimethylbenzoate, have been synthesized and characterized by elemental analysis, FT-IR, multinuclear NMR (1H, 13C and 119Sn), mass spectrometry and single crystal X-ray structural analysis. Crystallographic data show that in compounds 1 and 2, the geometry at the central Sn atom is skew-trapezoidal bipyramidal while compound 3 displays a distorted trigonal bipyramidal coordination geometry. In the case of compounds 1 and 2, the asymmetric chelati...
8 Citations Source Cite
Published on Dec 1, 2012in European Journal of Medicinal Chemistry 4.83
Handong Yin14
Estimated H-index: 14
(Liaocheng University),
Caihong Yue4
Estimated H-index: 4
(Liaocheng University)
+ 3 AuthorsXiuyun Zhang3
Estimated H-index: 3
(Liaocheng University)
Abstract Reactions of the diorganotin with two N–OH diimide ligands ( N -hydroxyphthalimide and N -hydroxysuccinimide) yielded five new dimeric tetraorganostannoxanes formulated as R 8 Sn 4 O 2 L 2 X 2 . The crystal structures of the complexes reveal the formation of the tetranuclear species contains a planar Sn 4 O 4 core, consisting of three adjacent rhombs with bridging oxo and N–OH diimide ligands. The central tin atoms are five-coordinated to assume a distorted trigonal bipyramidal configur...
21 Citations Source Cite
Published on May 27, 2011in Materials 2.97
Michael R. Roner19
Estimated H-index: 19
,
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
+ 1 AuthorsGirish Barot11
Estimated H-index: 11
(BU: Boston University)
Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very ...
17 Citations Source Cite
Girish Barot11
Estimated H-index: 11
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 3 AuthorsCharles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
A variety of dibutyltin polyethers have been synthesized employing the interfacial polymerization technique. The products are polymers with degrees of polymerization ranging from 60 to 390. Infrared spectral and mass spectral results are consistent with the proposed structure. The products show good inhibition of a variety of cancer cells including those associated with bone, breast, prostrate, and lung cancers. Some also show good viral inhibition of the HSV-1 (herpes simplex) and Vaccina (smal...
26 Citations Source Cite
Published on Jan 1, 2008in ChemInform
Lorenzo Pellerito7
Estimated H-index: 7
,
Tiziana Fiore14
Estimated H-index: 14
+ 4 AuthorsEniko Nagy4
Estimated H-index: 4
(MTA: Hungarian Academy of Sciences)
4 Citations Source Cite
Published on Jan 1, 2008
Metal complexes generally and organotin(IV) compounds especially are used routinely in several biomedical and commercial applications like agricultural biocides, disinfectants, antitumor agents, wood preservatives, antioxidants, stabilizers for polyvinylchloride, marine antifouling coating, anti-herpes agents, flame retardants, smoke suppressants, anti-wear agents, homogenous catalysts and recycling agents. A number of organotin compounds have been shown to be toxic, and there is increasing conc...
Girish Barot11
Estimated H-index: 11
(FAU: Florida Atlantic University),
Kimberly Shahi10
Estimated H-index: 10
(UTA: University of Texas at Arlington)
+ 1 AuthorsCharles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
A series of organotin poly(ethylene glycols) were synthesized including the first water soluble organotin polymers. These products are all polymeric with weight average molecular weights about 105. Infrared spectroscopy shows the presence of moieties from both reactants and the formation of the Sn–O linkage. F MALDI MS shows the presence of up to over a hundred units and by isotopic abundance the presence of one, two, and three tin-containing ion fragments. The polymers inhibit the growth of can...
34 Citations Source Cite
Published on Jul 1, 2006in Bulletin of the Chemical Society of Japan 4.43
Muslim Khan4
Estimated H-index: 4
,
Musa Kaleem Baloch13
Estimated H-index: 13
+ 1 AuthorsAbdul Malik30
Estimated H-index: 30
Five new diorganotin(IV) complexes of the general composition [R' 2 SnR 2 ] (where R': Me, Et, Bu, Ph, Bn and R: N-maleoyltranexamic acid) have been prepared and structurally characterized by means of FT IR and 119m Sn Mossbauer spectroscopy in the solid state. The solution-state structures were determined by means of multinuclear NMR ( 1 H, 13 C, and 119 Sn) spectroscopies. The spectroscopic data explained the 1:2 metal to ligand stoichiometry and hypervalency of Sn IV in a trans-octahedral arr...
3 Citations Source Cite