Cytotoxic activity of bis-[di-n-butyl(4-aminosalicylato)tin] oxide, NSC: 628561, bis-[diphenyl(4-aminosalicylato)tin] oxide, NSC: 628562, and some related compounds, against a series of human tumour cell lines.

Published on Jan 1, 1992in Anticancer Research 1.86
Marcel Gielen32
Estimated H-index: 32
,
Rudolph Willem37
Estimated H-index: 37
Abstract
Bis[di-n-butyl (4-aminosalicylato)tin] oxide [NSC: 628561] (compound 1), bis [diphenyl(4-aminosalicylato)tin] oxide [NSC: 628562] (compound 2), and six other analogous compounds of the type [n-Bu2 (XYZ-C6H2COO)Sn]2O (compounds 3 to 8), were tested in vitro at the National Cancer Institute, Bethesda, Maryland, USA, for cytotoxic activity against a series of human cell lines. Compounds 1, 6 and 8 score globally satisfactorily since four of the five relevant sensitivity or selectivity parameters, DGI50, DTGI or DLC50, DH and MGDH, are statistically significant. Compounds 3 and 7 are less satisfactory because only three such parameters are statistically significant. For compound 2, only two of the parameters are significant.
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Cited By28
Published on Dec 1, 2012in European Journal of Medicinal Chemistry 4.82
Handong Yin13
Estimated H-index: 13
(Liaocheng University),
Caihong Yue4
Estimated H-index: 4
(Liaocheng University)
+ 3 AuthorsXiuyun Zhang3
Estimated H-index: 3
(Liaocheng University)
Abstract Reactions of the diorganotin with two N–OH diimide ligands ( N -hydroxyphthalimide and N -hydroxysuccinimide) yielded five new dimeric tetraorganostannoxanes formulated as R 8 Sn 4 O 2 L 2 X 2 . The crystal structures of the complexes reveal the formation of the tetranuclear species contains a planar Sn 4 O 4 core, consisting of three adjacent rhombs with bridging oxo and N–OH diimide ligands. The central tin atoms are five-coordinated to assume a distorted trigonal bipyramidal configur...
20 Citations Source Cite
Published on Sep 1, 1996in Applied Organometallic Chemistry 3.58
V. S. Petrosyan18
Estimated H-index: 18
,
N.S. Yashina9
Estimated H-index: 9
+ 3 AuthorsL. Pellerito21
Estimated H-index: 21
(University of Palermo)
Several di-n-butyltin and diethyltin biscarboxylates and distannoxanes of α-methoxy- and α-acetoxy-phenylacetic acids were synthesized and (two of) their structures were studied by means of X-ray diffraction analysis as well as by means of IR and Mossbauer spectroscopies. It was shown for {[(n-Bu) 2 - SnOC(O)CH(OMe)Ph] 2 O} 2 that there is an interaction between the OMe group and one of the endocyclic tin atoms, resulting in a distorted pentagonal-bipyramidal geometry with the pentagonal plane d...
7 Citations Source Cite
Published on Jul 1, 1997in Applied Organometallic Chemistry 3.58
Siu-Choon Ng29
Estimated H-index: 29
(National University of Singapore),
Peter G. Parsons43
Estimated H-index: 43
(QIMR Berghofer Medical Research Institute)
+ 3 AuthorsRodney H. White4
Estimated H-index: 4
(Griffith University)
Six dibutyl-1,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80–13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour ag...
8 Citations Source Cite
Published on Apr 1, 2005in Applied Organometallic Chemistry 3.58
Marcel Gielen32
Estimated H-index: 32
(Vrije Universiteit Brussel),
Monique Biesemans34
Estimated H-index: 34
(Vrije Universiteit Brussel),
Rudolph Willem37
Estimated H-index: 37
(Vrije Universiteit Brussel)
An overview is given of the research performed by the authors at the Universite Libre de Bruxelles and Vrije Universiteit Brussel, including the kinetics, stereochemistry and mechanism of SE2 reactions at a saturated carbon atom, the synthesis of chiral organotin compounds and their configurational and optical stability, the fluxionality of trigonal bipyramidal metal atoms and the stereochemistry of SN2 reactions at tetrahedrally substituted P, Si, Ge, Sn atoms, the cytotoxicity of many series o...
156 Citations Source Cite
Published on Apr 1, 2006in Journal of Organometallic Chemistry 1.95
Claudia Pellerito14
Estimated H-index: 14
(University of Palermo),
László Nagy24
Estimated H-index: 24
(University of Szeged)
+ 1 AuthorsAttila Szorcsik11
Estimated H-index: 11
(University of Szeged)
This review summarized the literature and own data on the parent organotin(IV) compounds and complexes formed with biologically active ligands.
128 Citations Source Cite
Published on Apr 1, 1993in Applied Organometallic Chemistry 3.58
Marcel Gielen32
Estimated H-index: 32
(Free University of Brussels),
Abdelaziz El Khloufi8
Estimated H-index: 8
(Free University of Brussels)
+ 1 AuthorsRudolph Willem37
Estimated H-index: 37
(Free University of Brussels)
The di-n-butyltin(IV) and diethyltin(IV) fluorobenzoates [FC6H4COO]2SnR2 and (FC6H4COOR2Sn)2O have been synthesized and characterized spectroscopically. Their in vitro antitumor activity against two human tumor cell lines, MCF-7, a mammary tumor, and WiDr, a colon carcinoma, as well as against the NCI cell panel, is satisfactory.
50 Citations Source Cite
Girish Barot11
Estimated H-index: 11
(Florida Atlantic University),
Kimberly Shahi10
Estimated H-index: 10
(University of Texas at Arlington)
+ 1 AuthorsCharles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University)
A series of organotin poly(ethylene glycols) were synthesized including the first water soluble organotin polymers. These products are all polymeric with weight average molecular weights about 105. Infrared spectroscopy shows the presence of moieties from both reactants and the formation of the Sn–O linkage. F MALDI MS shows the presence of up to over a hundred units and by isotopic abundance the presence of one, two, and three tin-containing ion fragments. The polymers inhibit the growth of can...
34 Citations Source Cite
Published on Oct 1, 2004in Journal of Organometallic Chemistry 1.95
Mohammad Iqbal Khan4
Estimated H-index: 4
(Gomal University),
Musa Kaleem Baloch13
Estimated H-index: 13
(Gomal University),
Muhammad Ashfaq11
Estimated H-index: 11
(Islamia University)
Abstract Four new compounds of organic mono carboxylic acid, 3-maleimidopropionic acid; with Bu 2 Sn(IV) 2+ , Ph 3 Sn(IV) + and Cychex 3 Sn(IV) + having ligand to metal ratio 1:2 and 1:1 were prepared. The spectrophotometric techniques used for structure determination like 1 H-, 13 C- and 119 Sn-NMR, FT IR and 119m Sn Mossbauer have demonstrated that the organotin(IV) moieties establish chemical bonding with the ligand through carboxylic oxygen atom. The percent CHN analyses and MS data also cor...
59 Citations Source Cite
Published on Jan 1, 2002in Coordination Chemistry Reviews 14.50
L. Pellerito21
Estimated H-index: 21
(University of Palermo),
László Nagy24
Estimated H-index: 24
(University of Szeged)
Abstract The organotin(IV) cations form complexes with ligands containing {O}, {N}, {S}, or {phosphorus(O)} donor atoms with various composition and stability. The emergence of new experimental techniques (EXAFS, multinuclear 1 H-, 13 C-, 119 Sn-NMR, 119 Sn Mossbauer, etc., spectroscopic techniques) provided useful information about the structure and stabilities of the complexes formed. We reviewed the literature on these type of complexes taking into account the biological aspects of the comple...
446 Citations Source Cite
Published on May 1, 1993in Applied Organometallic Chemistry 3.58
Marcel Gielen32
Estimated H-index: 32
(Free University of Brussels),
Abdelaziz El Khloufi8
Estimated H-index: 8
(Free University of Brussels)
+ 2 AuthorsRudolph Willem37
Estimated H-index: 37
(Free University of Brussels)
The synthesis and characterization by spectroscopy of several new di-n-butyltin and diethyltin 2-fluorocinnamates and 4-fluorophenylacetates are described. In vitro tests on two human tumour cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma, showed that two of these compounds are more active than cisplatin. Other in vitro tests performed by the NCI, USA on a panel of human tumour cell line show that one of them, bis[di-n-butyl(2-fluorophenylacetato)tin] oxide, is characterized by ...
57 Citations Source Cite