A modified LC‐MS/MS method for determination of tetramethylpyrazine in microdialysis samples and calibration of home‐made linear probes
Abstract
Tetramethylpyrazine (TMP) is one of the most important active ingredients of a Chinese herb Ligusticum wallichii Franchat, which is widely used for the treatment of cardiovascular diseases. Several factors may affect TMP exposure after topical administration, resulting in large variability and demanding further elucidation of drug distribution. This paper describes a new efficient reliable LC-MS/MS assay for the determination of TMP in dermal...
Paper Details
Title
A modified LC‐MS/MS method for determination of tetramethylpyrazine in microdialysis samples and calibration of home‐made linear probes
Published Date
Feb 15, 2012
Journal
Volume
26
Issue
10
Pages
1276 - 1281
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