A 1‐hour pulse with IL‐1β induces formation of nitric oxide and inhibits insulin secretion by rat islets of Langerhans: evidence for a tyrosine kinase signaling mechanism

Nitric oxide has been implicated as the effector molecule that mediates interlcukin-1β (IL-1β)-in-duced inhibition of glucose-stimulated insulin secretion by rat islets. Brief exposures of islets (1 h) to IL-1β have been shown to inhibit glucose-stimulated insulin secretion at 8 or 18 h after removal of this cytokine. The purpose of this investigation was to determine if brief exposures of islets to IL-1β are sufficient to induce the formation...