Review paper
High fat diet modulation of glucose sensing in the beta-cell.
Abstract
Type 2 diabetes is primarily associated with beta-cell failure, insulin resistance and elevated hepatic glucose production. The islet beta-cell is specialized for the synthesis, storage and secretion of insulin. Beta-cell failure is characterized by the inability of the beta-cell to secrete sufficient insulin in response to glucose, which ultimately results in hyperglycemia- the clinical hallmark of Type 2 diabetes. Impairment in glucose sensing...
Paper Details
Title
High fat diet modulation of glucose sensing in the beta-cell.
Published Date
Jan 1, 2007
Journal
Volume
13
Issue
1
Pages
RA12 - 7
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