Preparative Production of Acetylcholinesterase and Paraoxonase in Procaryotic and Eucaryotic Expression in Systems
Published: Jul 1, 2003
Abstract
: The acute toxicity of organophosphate (OP) compounds in mammals in general, and in humans in particular, is generally ascribed to their irreversible inhibition of acetyicholinesterase (AChE), the enzyme that terminates the action of acetylcholine (ACh) at cholinergic synapses by its rapid hydrolysis (1). Current medical protection against OPs involves anticholinergic drugs to counteract the accumulation of ACh (2), and quatemary oximes to...
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