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Theory and Practice of Microdialysis — Prospect for Future Clinical Use
Published on Jan 1, 1999in Acta neurochirurgica 1.93
· DOI :10.1007/978-3-7091-6415-0_1
L. Hillered1
Estimated H-index: 1
(Uppsala University Hospital),
L. Persson1
Estimated H-index: 1
(Uppsala University Hospital)
Abstract
The application of microdialysis for neurochemical monitoring in neurosurgery and neurointensive care is rapidly expanding in a number of clinical centers around the world. In order for microdialysis to become a future routine method in these clinical settings a number of problems, outlined in this communication, must be solved by the clinical researchers and the commercial companies. Regardless of the future success as a routine method, it is already obvious that microdialysis will be an important clinical research tool for years to come, providing new important insights into the pathophysiology of acute human brain injury.
  • References (19)
  • Cited By (22)
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References19
Published on Jan 1, 1996in Acta neurochirurgica 1.93
J. C. Goodman15
Estimated H-index: 15
(Baylor College of Medicine),
Shankar P. Gopinath31
Estimated H-index: 31
(Baylor College of Medicine)
+ 4 AuthorsClaudia S. Robertson67
Estimated H-index: 67
(Baylor College of Medicine)
We examined the extracellular neurochemical milieu in 34 head injured patients using microdialysis while simultaneously monitoring intracranial pressure, cerebral perfusion pressure, and jugular venous oxygen saturation. Derangements of anaerobic metabolism reflected by increased lactate and lactate/pyruvate ratios, and release of amino acids were seen at the same time as physiological deterioration in the majority of instances. Clinical microdialysis may provide insights into the neurochemistry...
32 Citations Source Cite
Published on Jan 1, 1991
Terry E. Robinson87
Estimated H-index: 87
,
J. B. Justice1
Estimated H-index: 1
Preface. List of Contributors. SECTION I: Introduction to Microdialysis. Introduction to intracerebral microdialysis (U. Ungerstedt). Microdialysis compared with other in vivo release models (B.H.C. Westerink, J.B. Justice, Jr.). SECTION II: Issues of Quantification. Quantitative microdialysis (P.F. Morrison et al.). Practical aspects of using microdialysis for determination of brain interstitial concentrations (H. Benveniste, A.J. Hansen). SECTION III: Methodological Considerations. Microdialys...
279 Citations
Published on Sep 1, 1995in Annals of the New York Academy of Sciences 4.28
Ross Bullock59
Estimated H-index: 59
(VCU Medical Center),
Alois Zauner26
Estimated H-index: 26
(VCU Medical Center)
+ 3 AuthorsHarold F. Young41
Estimated H-index: 41
(VCU Medical Center)
136 Citations Source Cite
Published on Jan 1, 1995in Journal of Neurotrauma 5.00
Claudia S. Robertson67
Estimated H-index: 67
(Baylor College of Medicine),
Shankar P. Gopinath31
Estimated H-index: 31
+ -2 AuthorsR. K. Narayan1
Estimated H-index: 1
ABSTRACT Jugular venous oxygen saturation (SjvO2) measures the balance between cerebral oxygen delivery and cerebral oxygen consumption. Abnormalities that increase oxygen consumption (e.g., fever or seizures) or that decrease oxygen delivery (e.g., increased ICP, hypotension, hypoxia, hypocapnia, or anemia) can decrease SjvO2. Measuring SjvO2 continuously in the ICU in 177 patients with severe head injury, jugular venous desaturation (SjvO2 < 50%) was identified at least once in 39% of the pati...
131 Citations Source Cite
Published on May 1, 1991in Epilepsy Research 2.49
Anders Hamberger48
Estimated H-index: 48
(University of Gothenburg),
Britta Nyström12
Estimated H-index: 12
(University of Gothenburg)
+ 2 AuthorsClaes Nordborg29
Estimated H-index: 29
Abstract Extracellular fluid was topically sampled with a dialysis probe during electrocorticography from the exposed cerebral cortex in 23 patients undergoing epilepsy surgery. Sampling was done in parallel from epileptiform regions and from non-epileptic areas. The former were classified according to the histopathology, into neoplastic, non-tumoral or ‘special cases’. The epileptiform regions had significantly higher extracellular concentrations of alanine, glycine and phosphoethanolamine in t...
51 Citations Source Cite
Published on Jun 1, 1993in Neurosurgery 4.47
Hans Landolt8
Estimated H-index: 8
,
Helen Langemann8
Estimated H-index: 8
,
Otmar Gratzl7
Estimated H-index: 7
AN ON-LINE pH meter that can be mounted in microdialysis systems is described. The pH monitoring system was tested in rat cortex before and after middle cerebral artery occlusion (focal ischemia model). After probe implantation, pH values in the dialysate quickly reached a stable level that depended on perfusion medium (6.72, Ringer; 6.47, 0.9% saline) and flow rate (2 μl/min). During ischemia, pH values sank rapidly and significantly, whereas lactic and ascorbic acid levels in the dialysate inc...
24 Citations Source Cite
Published on Sep 1, 1990in Acta Neurochirurgica
Lars Hillered53
Estimated H-index: 53
,
Lennart Persson10
Estimated H-index: 10
+ 1 AuthorsUrban Ungerstedt95
Estimated H-index: 95
(Karolinska Institutet)
Recent animal research has provided evidence that brain ischaemia is associated with a shift of energy related metabolites (lactate, adenosine, inosine, and hypoxanthine) and several transmitters from the intracellular to the extracellular fluid (ECF). These chemical changes of the ECF reflect the energy crisis of the ischaemic tissue. We have proposed that measurement of these metabolites in the ECF using microdialysis may be a useful technique for detection of secondary ischaemia in neurosurgi...
189 Citations Source Cite
Published on Jan 1, 1990in Life Sciences 3.23
B.A. Meyerson1
Estimated H-index: 1
,
B. Linderoth1
Estimated H-index: 1
+ 1 AuthorsUrban Ungerstedt95
Estimated H-index: 95
(Karolinska Institutet)
Abstract Microdialysis in the human brain has been performed for the first time during thalamotomy intended to relieve tremor in patients with Parkinson's disease. The aim was to test the reliability of the microdialysis technique for biochemical characterization of a target area in the human brain during a routine operation. Microdialysis probes were introduced through the same trajectory as the lesioning electrode thus causing no additional damage to the brain. Dopamine, DOPAC, HVA, 5-HIAA, hy...
131 Citations Source Cite
Published on May 1, 1996in European Journal of Anaesthesiology 3.98
H. Landolt1
Estimated H-index: 1
,
H. Langemann1
Estimated H-index: 1
In the past 10 years, the management of brain injury has shown several advances. Besides new diagnostic tools many new tentative approaches have been investigated, such as jugular bulb measurement of oxygen and lactate differences and near-infrared spectroscopy. The latest tool is microdialysis, which uses a probe as an interface to the brain. This method uses internally perfused semi-permeable membrane probes, which allow neurochemical water-soluble substances to be collected outside the brain ...
36 Citations Source Cite
Cited By22
Gérard Audibert17
Estimated H-index: 17
,
Claire Charpentier5
Estimated H-index: 5
,
Paul-Michel Mertes27
Estimated H-index: 27
Published on Jan 1, 2005
Aina Ågren Wilsson1
Estimated H-index: 1
The symptoms in Idiopathic Adult Hydrocephalus Syndrome (IAHS) – gait disturbance, incontinence, and cognitive deficit – correlate anatomically to neuronal dysfunction in periventricular white matt ...
1 Citations
Markus W. Löffler8
Estimated H-index: 8
(University of Tübingen),
Heiko Schuster12
Estimated H-index: 12
(University of Tübingen)
+ 1 AuthorsStefan Beckert16
Estimated H-index: 16
(University of Tübingen)
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been describ...
8 Citations Source Cite
Published on May 1, 2002in Liver Transplantation 3.76
Grzegorz Nowak8
Estimated H-index: 8
(Karolinska Institutet),
Johan Ungerstedt5
Estimated H-index: 5
(Karolinska Institutet)
+ 2 AuthorsBo-Göran Ericzon35
Estimated H-index: 35
(Karolinska Institutet)
Abstract Microdialysis provides the opportunity to continuously monitor metabolic changes in tissue. The aim of the study is to monitor metabolic changes in the liver graft over time during transplantation in a pig model. Fourteen littermate female pigs with a body weight of 30 to 34 kg were used for seven orthotopic liver transplantations. Intrahepatic implantation of a microdialysis catheter into the liver graft was performed in the donor. Microdialysis samples were collected at 20-minute inte...
68 Citations Source Cite
Published on Feb 1, 2008in Journal of Gastrointestinal Surgery 2.81
Anne-Sofie Kannerup7
Estimated H-index: 7
(Aarhus University Hospital),
Peter Funch-Jensen39
Estimated H-index: 39
(Aarhus University Hospital)
+ 2 AuthorsFrank Viborg Mortensen17
Estimated H-index: 17
(Aarhus University Hospital)
Aim Portal triad clamping can cause ischemia–reperfusion injury. The aim of the study was to monitor metabolic changes by microdialysis before, during, and after warm ischemia in the pigliver.
25 Citations Source Cite
Published on Jul 1, 2001in Neurological Research 1.45
Helen Langemann8
Estimated H-index: 8
,
Beat Alessandri20
Estimated H-index: 20
+ 3 AuthorsOtmar Gratzl14
Estimated H-index: 14
AbstractThe aim of this study was to use quantitative microdialysis to estimate the true extracellular concentrations of glucose and lactate in minimally disturbed human brain. These values are important as criteria for microdialytical monitoring in critical care patients and for determining therapy. Microdialysis procedures were carried out during tumor operations, the probe being inserted distant from the site of manipulation in minimally disturbed tissue. Two methods were used: 1. The zero ne...
32 Citations Source Cite
Published on Jan 1, 2008in Mass Spectrometry Reviews 9.53
Martin H. Maurer29
Estimated H-index: 29
(Heidelberg University)
Mass spectrometry has become the gold standard for the identification of proteins in proteomics. In this review, I will discuss the available literature on proteomic experiments that analyze human cerebrospinal fluid (CSF) and brain extracellular fluid (ECF), mostly obtained by cerebral microdialysis. Both materials are of high diagnostic value in clinical neurology, for example, in cerebrovascular disorders like stroke, neurodegenerative diseases like Alzheimer's Disease, Parkinson's Disease, a...
61 Citations Source Cite
Published on Jan 1, 2010in European Surgical Research 1.34
A.-S. Kannerup1
Estimated H-index: 1
,
Henning Grønbæk29
Estimated H-index: 29
(Aarhus University Hospital)
+ 2 AuthorsFrank Viborg Mortensen17
Estimated H-index: 17
Background: Temporary vascular in- and outflow occlusion is an effective technique for bleeding control during liver resection. However, occlusion can result in ischemia/reperfusion
1 Citations Source Cite
Published on Feb 1, 2010in Childs Nervous System 1.24
Constantinos Charalambides2
Estimated H-index: 2
,
Spyros Sgouros24
Estimated H-index: 24
,
Damianos Sakas1
Estimated H-index: 1
Introduction Cerebral microdialysis is a relatively new, minimally invasive technique that permits sampling and analyzing the chemical constituents of the extracellular fluid. Although mainly used as a research tool, it is also used in the neurointensive care, in combination with other monitoring methods, in patients with severe traumatic brain injury and subarachnoid hemorrhage. Its main clinical utility is the identification of markers of ischemia and cell damage with the ultimate goal of prev...
11 Citations Source Cite
Gérard Audibert17
Estimated H-index: 17
,
Claire Charpentier5
Estimated H-index: 5
,
Paul-Michel Mertes27
Estimated H-index: 27
Resume La microdialyse est la seule technique permettant la surveillance du metabolisme cerebral en clinique. Elle permet, par l'intermediaire d'une sonde implantee dans le parenchyme cerebral, d'en obtenir des echantillons de liquide interstitiel. Des dosages de substrats peuvent ensuite etre realises. Des automates permettent d'obtenir au lit du patient le taux cerebral de glucose, lactate, pyruvate, glycerol ou glutamate, avec des intervalles de dosage variant entre quelques minutes a quelque...
1 Citations Source Cite
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