mtDNA mutations variously impact mtDNA maintenance throughout the human embryofetal development.
Abstract
Mitochondria are the largest generator of ATP in the cell. It is therefore expected that energy-requiring processes such as oocyte maturation, early embryonic or fetal development, would be adversely impacted in case of mitochondrial deficiency. Human mitochondrial DNA (mtDNA) mutations constitute a spontaneous model of mitochondrial failure and offer the opportunity to study the consequences of energetic defects over fertility and embryofetal...
Paper Details
Title
mtDNA mutations variously impact mtDNA maintenance throughout the human embryofetal development.
Published Date
Nov 1, 2015
Journal
Volume
88
Issue
5
Pages
416 - 424
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Notes
History