Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism.

To contrast the effects of total sleep deprivation (TSD) on executive and non-executive function in volunteers homozygous for either the short or long variant of a variable number tandem repeat polymorphism in PERIODS, which is a genetic marker for susceptibility to the negative effect of sleep loss on waking performance.Following two laboratory nights of baseline sleep, both groups underwent an approximately 40-hour constant routine, performing...