Circulating human B cells that express surrogate light chains and edited receptors

Immunoglobulin gene recombination can result in the assembly of self-reactive antibodies. Deletion, anergy or receptor editing normally silence B cells that produce these autoantibodies. Receptor editing is highly efficient in mouse B cells that carry pre-recombined autoantibody transgenes or gene knock-ins. However, it has been difficult to identify cells that have edited receptors in unmanipulated mice and humans. To try to identify such cells...