Extracellular Histones Inhibit Efferocytosis
Abstract
The uptake and clearance of apoptotic cells by macrophages and other phagocytic cells, a process called efferocytosis, is a major component in the resolution of inflammation. Increased concentrations of extracellular histones are found during acute inflammatory states and appear to contribute to organ system dysfunction and mortality. In these studies, we examined the potential role of histones in modulating efferocytosis. We found that...
Paper Details
Title
Extracellular Histones Inhibit Efferocytosis
Published Date
Apr 4, 2012
Journal
Volume
18
Issue
5
Pages
825 - 833
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