On‐line reaction monitoring by extractive electrospray ionisation

The design and development of a novel extractive electrospray ionisation (EESI) device for on‐line reaction monitoring is described. The EESI apparatus uses a secondary, grounded nebuliser to produce an analyte aerosol and a Venturi pump is then used to transfer a sample of the aerosol to an electrospray source where it is ionised. The EESI apparatus was then tested with a variety of small, organic molecules to assess sensitivity, linearity and...