The “Subsyndromal” Syndromes of Aging

There has been much recent interest in the clinical significance of low-grade psychopathology (symptoms insufficient to allow a formal psychiatric diagnosis). Such subsyndromal presentations were first described in the context of mood disorder (e.g., subsyndromal depression),1 then later extended to cognitive disorders (e.g., mild cognitive impairment (MCI)).2 Recently, some have3 proposed the idea of subsyndromal delirium. It is time to take a...