Allelic exclusion of immunoglobulin genes: models and mechanisms
Abstract
Summary: The allelic exclusion of immunoglobulin (Ig) genes is one of the most evolutionarily conserved features of the adaptive immune system and underlies the monospecificity of B cells. While much has been learned about how Ig allelic exclusion is established during B‐cell development, the relevance of monospecificity to B‐cell function remains enigmatic. Here, we review the theoretical models that have been proposed to explain the...
Paper Details
Title
Allelic exclusion of immunoglobulin genes: models and mechanisms
Published Date
Aug 19, 2010
Journal
Volume
237
Issue
1
Pages
22 - 42
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