Structural basis for retroviral integration into nucleosomes

Retroviruses such as HIV rely on the intasome, a tetramer of integrase protein bound to the viral DNA ends interacting with host chromatin, for integration into the host genome; the structure of the intasome as it interacts with a nucleosome is now solved, giving insight into the integration process. Retroviruses such as HIV have an RNA genome that is reverse-copied into double-stranded DNA, which subsequently inserts into the host genome. The...