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Coconut oil attenuates the effects of amyloid-β on cortical neurons in vitro.

Published on Jan 24, 2014in Journal of Alzheimer's Disease3.70
· DOI :10.3233/JAD-131436
Firoozeh Nafar4
Estimated H-index: 4
(MUN: Memorial University of Newfoundland),
Karen M. Mearow19
Estimated H-index: 19
(MUN: Memorial University of Newfoundland)
Abstract
Dietary supplementation has been studied as an approach to ameliorating deficits associated with aging and neurode- generation. We undertook this pilot study to investigate the effects of coconut oil supplementation directly on cortical neurons treated with amyloid- (A) peptide in vitro. Our results indicate that neuron survival in cultures co-treated with coconut oil and A is rescued compared to cultures exposed only to A. Coconut oil co-treatment also attenuates A-induced mitochondrial alterations. The results of this pilot study provide a basis for further investigation of the effects of coconut oil, or its constituents, on neuronal survival focusing on mechanisms that may be involved.
  • References (22)
  • Citations (15)
References22
Newest
#1Brian DuBoff (Brigham and Women's Hospital)H-Index: 4
#2Mel B. Feany (Brigham and Women's Hospital)H-Index: 48
Last.Jürgen Götz (UQ: University of Queensland)H-Index: 54
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#1Yoshihiro Kashiwaya (NIH: National Institutes of Health)H-Index: 21
#2Christian Bergman (NIH: National Institutes of Health)H-Index: 3
Last.Richard L. Veech (NIH: National Institutes of Health)H-Index: 45
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#1Piotr Wlaź (UMCS: Maria Curie-Skłodowska University)H-Index: 22
#2Katarzyna Socała (UMCS: Maria Curie-Skłodowska University)H-Index: 10
Last.Maciej Gasior (BMS: Bristol-Myers Squibb)H-Index: 4
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Cited By15
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#1Renan da Silva Lima (UFSC: Universidade Federal de Santa Catarina)
#2Jane Mara Block (UFSC: Universidade Federal de Santa Catarina)H-Index: 11
#1Ananya Bansal (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
#2Megan Kirschner (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
Last.Lumin Zhang (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
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#1Yasunori Nishimura (OPU: Osaka Prefecture University)H-Index: 1
#2Mitsuaki Moriyama (OPU: Osaka Prefecture University)H-Index: 16
Last.Yoichi Nakamura (OPU: Osaka Prefecture University)H-Index: 17
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#1Senthilkumar Sankararaman (Case Western Reserve University)H-Index: 1
#2Thomas J. Sferra (Case Western Reserve University)H-Index: 22
#1Fatemeh Mirzaei (Kermanshah University of Medical Sciences)H-Index: 1
#2Mozafar Khazaei (Kermanshah University of Medical Sciences)H-Index: 12
Last.Cyrus Jalili (Kermanshah University of Medical Sciences)H-Index: 8
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#1Katrin Augustin (RHUL: Royal Holloway, University of London)H-Index: 2
#2Aziza Khabbush (UCL: University College London)H-Index: 2
Last.Robin S. B. Williams (RHUL: Royal Holloway, University of London)H-Index: 26
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#1Firoozeh Nafar (MUN: Memorial University of Newfoundland)H-Index: 4
#2Joseph P. Clarke (MUN: Memorial University of Newfoundland)H-Index: 3
Last.Karen M. Mearow (MUN: Memorial University of Newfoundland)H-Index: 19
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