Coconut oil attenuates the effects of amyloid-β on cortical neurons in vitro.

Published on Jan 24, 2014in Journal of Alzheimer's Disease3.70
· DOI :10.3233/JAD-131436
Firoozeh Nafar4
Estimated H-index: 4
(MUN: Memorial University of Newfoundland),
Karen M. Mearow19
Estimated H-index: 19
(MUN: Memorial University of Newfoundland)
Dietary supplementation has been studied as an approach to ameliorating deficits associated with aging and neurode- generation. We undertook this pilot study to investigate the effects of coconut oil supplementation directly on cortical neurons treated with amyloid- (A) peptide in vitro. Our results indicate that neuron survival in cultures co-treated with coconut oil and A is rescued compared to cultures exposed only to A. Coconut oil co-treatment also attenuates A-induced mitochondrial alterations. The results of this pilot study provide a basis for further investigation of the effects of coconut oil, or its constituents, on neuronal survival focusing on mechanisms that may be involved.
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