Expression of Alkaline Protease Gene inBacillus subtilisMutants That Lack Positive Regulatory GenesdegR, degQ,senS, tenA, andproB

In addition to the two-component regulatory system, DegS-DegU, five other genes degR, degQ, senS, tenA, and proB positively regulate the production of Bacillus subtilis exoproteases when they are present on a multicopy plasmid. To study the extent of involvement of these genes in exoprotease production in a single copy state and possible relationship among these genes, strains carrying single or multiple disruption mutations in these loci were...