Effects ofChlorellaon Activities of Protein Tyrosine Phosphatases, Matrix Metalloproteinases, Caspases, Cytokine Release, B and T Cell Proliferations, and Phorbol Ester Receptor Binding

A Chlorella powder was screened using 52 in vitro assay systems for enzyme activity, receptor binding, cellular cytokine release, and B and T cell proliferation. The screening revealed a very potent inhibition of human protein tyrosine phosphatase (PTP) activity of CD45 and PTP1C with 50% inhibitory concentration (IC50) values of 0.678 and 1.56 μg/mL, respectively. It also showed a moderate inhibition of other PTPs, including PTP1B (IC50 = 65.3...