Developmental plasticity of red blood cell homeostasis

Most human physiologic set points like body temperature are tightly regulated and show little variation between healthy individuals. Red blood cell (RBC) characteristics such as hematocrit and mean cell volume are stable within individuals but can vary by 20% from one healthy person to the next. The mechanisms for the majority of this inter‐individual variation are unknown and do not appear to involve common genetic variation. Here, we show that...