Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
Abstract
Various molecules such as cytokines and anticancer drugs, as well as factor deprivation, rapidly induce apoptosis (programmed cell death), which is morphologically characterized by cell shrinkage and the blebbing of plasma membranes and by nuclear condensation. Caspases, particularly caspase 3, are proteases that are activated during apoptosis and which cleave substrates such as poly(ADP-ribose) polymerase, actin, fodrin, and lamin. Apoptosis is...
Paper Details
Title
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
Published Date
Jan 1, 1998
Journal
Volume
391
Issue
6662
Pages
96 - 99
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