Increase in visceral fatper sedoes not induce insulin resistance in the canine model

To determine whether a selective increase of visceral adipose tissue content will result in insulin resistance.Sympathetic denervation of the omental fat was performed under general inhalant anesthesia by injecting 6-hydroxydopamine in the omental fat of lean mongrel dogs (n = 11). In the conscious animal, whole-body insulin sensitivity was assessed by the minimal model (SI ) and the euglycemic hyperinsulinemic clamp (SICLAMP ). Changes in...