Original paper
Interleukin‐4 and interleukin‐13 compromise the sinonasal epithelial barrier and perturb intercellular junction protein expression
Volume: 4, Issue: 5, Pages: 361 - 370
Published: Feb 7, 2014
Abstract
Background Altered expression of epithelial intercellular junction proteins has been observed in sinonasal biopsies from nasal polyps and epithelial layers cultured from nasal polyp patients. These alterations comprise a “leaky” epithelial barrier phenotype. We hypothesize that T helper 2 (Th2) cytokines interleukin (IL)‐4 and IL‐13 modulate epithelial junction proteins, thereby contributing to the leaky epithelial barrier. Methods...
Paper Details
Title
Interleukin‐4 and interleukin‐13 compromise the sinonasal epithelial barrier and perturb intercellular junction protein expression
Published Date
Feb 7, 2014
Volume
4
Issue
5
Pages
361 - 370
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