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Immune aging, dysmetabolism, and inflammation in neurological diseases.

Published on Jun 3, 2015in Frontiers in Neuroscience3.648
· DOI :10.3389/fnins.2015.00172
Michela Deleidi10
Estimated H-index: 10
(German Center for Neurodegenerative Diseases),
Madeline Jäggle1
Estimated H-index: 1
(German Center for Neurodegenerative Diseases),
Graziella Rubino3
Estimated H-index: 3
(University of Tübingen)
Abstract
As we age, the immune system undergoes a process of senescence accompanied by the increased production of proinflammatory cytokines, a chronic subclinical condition named as "inflammaging". Emerging evidence from human and experimental models suggest that immune senescence also affects the central nervous system and promotes neuronal dysfunction, especially within susceptible neuronal populations. In this review we discuss the potential role of immune ageing, inflammation and metabolic derangements in neurological diseases. The discovery of novel therapeutic strategies targeting age-linked inflammation may promote healthy brain aging and the treatment of neurodegenerative as well as neuropsychiatric disorders.
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