Abstract 12: Prospective Associations of Fatty Acids in the De Novo Lipogenesis Pathway and Stearoyl CoA-desaturase-1 Activity with Risk of Type 2 Diabetes: the Cardiovascular Health Study

Background: Experimental evidence suggests de novo lipogenesis (DNL) affects insulin homeostasis via synthesis of saturated (SFA) and monounsaturated fatty acids (MUFA), and also through altered activity of the key regulatory enzyme, Stearoyl-CoA desaturase-1 (SCD-1). Only limited studies have utilized biomarkers of SFA, MUFA and estimated SCD-1 activity to assess their prospective association with risk of type 2 diabetes (T2D). Objective: To...