Recombinant WIF-1 domain protein up-regulates p27/KIP1 and p21/WAF-1 and inhibits cell proliferation of bladder cancer cells via G1 arrest
Volume: 67, Pages: 4377 - 4377
Published: May 1, 2007
Abstract
4377 null null Recent studies have demonstrated that down-regulation of secreted Wnt antagonists, including Wnt inhibitory factor-1 (WIF-1), through promoter hypermethylation is associated with invasive stage bladder cancer. To examine the biological effect of the secreted Wnt antagonist WIF-1 on bladder cancer cells, we have produced a recombinant protein containing the functional WIF-1 domain (WD) from null E.coli . Using L-cells, we showed...
Paper Details
Title
Recombinant WIF-1 domain protein up-regulates p27/KIP1 and p21/WAF-1 and inhibits cell proliferation of bladder cancer cells via G1 arrest
Published Date
May 1, 2007
Volume
67
Pages
4377 - 4377
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