Original paper
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
Abstract
The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocompatibility in vivo. In rodent and non-human primate animal models, implanted spheres 1.5 mm and above in diameter across a broad spectrum of materials, including hydrogels, ceramics, metals and plastics, significantly abrogated foreign body...
Paper Details
Title
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
Published Date
May 18, 2015
Journal
Volume
14
Issue
6
Pages
643 - 651
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Notes
History