Improving Parameter Estimation For A Decision-Analytic Markov Model To Evaluate The Use Of Novel Biomarker Led Strategies For Prevetion Of Cardiovascular Disease

This study sought to compare and improve the methods for estimating input parameters to populate a decision-analytic Markov model for use in the health economic assessment of novel biomarkers for primary prevention of Cardiovascular Disease. An initial five-state Markov model is built using the FINRISK97 cohort and follow-up for coronary and stroke events. Two different approaches to estimate the transition rates between health states are used....