APP processing enzymes (secretases) as therapeutic targets: insights from the use of transgenics (Tgs) and transfected cells.

Volume: 28, Issue: 7, Pages: 1049 - 1062
Published: Jul 1, 2003
Abstract
Secretases degrade amyloid precursor protein (APP) releasing fragments (β-peptides Aβ, Aβx) that assemble to form hallmark extracellular deposits in Alzheimer's disease (AD) correlating with disease severity. As such, secretases supply targets for therapeutic intervention and form the focus of this overview. Progress in elucidating secretases and their modes of catalysis come from exploiting the use of transgenics or transfected cells. In...
Paper Details
Title
APP processing enzymes (secretases) as therapeutic targets: insights from the use of transgenics (Tgs) and transfected cells.
Published Date
Jul 1, 2003
Volume
28
Issue
7
Pages
1049 - 1062
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