Multiscale modeling and control of crystal shape and size distributions: accounting for crystal aggregation, evaluation of continuous crystallization systems and run-to-run control

Crystallization plays a vital role in separation and purification methods for the production of therapeutic drugs. Considering the fact that crystal size and shape distributions have a significant influence on the bioavailability of drugs such as the dissolution rate, filterability, and stability as a carrier to the target site, the production of crystals with desired size and shape distributions is of particular interest to the pharmaceutical...