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Published on Feb 28, 2005in JAMA Internal Medicine 20.77
Ambika Babu3
Estimated H-index: 3
,
James Herdegen1
Estimated H-index: 1
+ 2 AuthorsTheodore Mazzone37
Estimated H-index: 37
Background: Sleep-disordered breathing (SDB) is a prevalent condition associated with significant comorbidities, including hypertension, obesity, cardiovascular disease, and insulin resistance. It has been previously shown that the severity of insulin resistance is related to the severity of SDB. Methods: Using a 72-hour continuous glucose monitoring system, we studied changes in interstitial glucose levels and measured hemoglobin A1c levels in 25 patients with type 2 diabetes mellitus before an...
365 Citations Source Cite
Published on Jan 1, 2005in Obesity Research
Robert Wolk30
Estimated H-index: 30
(Mayo Clinic),
Anna Svatikova17
Estimated H-index: 17
(Mayo Clinic)
+ 4 AuthorsVirend K. Somers96
Estimated H-index: 96
(Mayo Clinic)
Objective: Obstructive sleep apnea (OSA) is associated with obesity, sympathetic activation, systemic inflammation, and cardiovascular morbidity. Obesity, β-adrenergic agonists, and inflammation are linked to decreased expression and/or secretion of an adipose tissue-derived antiatherogenic hormone, adiponectin. The purpose of the study was to investigate whether OSA affected plasma levels of adiponectin, which might help explain OSA-associated cardiovascular morbidity. Research Methods and Proc...
75 Citations Source Cite
Published on Sep 1, 2004in The Journal of Clinical Endocrinology and Metabolism 5.61
Alexandros N. Vgontzas61
Estimated H-index: 61
,
Emmanuel Zoumakis14
Estimated H-index: 14
(NIH: National Institutes of Health)
+ 3 AuthorsGeorge P. Chrousos150
Estimated H-index: 150
(NIH: National Institutes of Health)
The proinflammatory cytokines, TNFα and IL-6, are elevated in obstructive sleep apnea (OSA) and have been proposed as mediators of excessive daytime sleepiness in humans. We tested the effects of etanercept, a medication that neutralizes TNFα and is approved by the FDA for the treatment of rheumatoid arthritis, in eight obese male apneics. These patients participated in a pilot, placebo-controlled, double-blind study during which nighttime polysomnography, multiple sleep latency test, and fastin...
262 Citations Source Cite
Published on Mar 1, 2004in Hypertension 7.02
Theodore L. Goodfriend30
Estimated H-index: 30
,
David A. Calhoun47
Estimated H-index: 47
Hypertension resistant to 2 antihypertensive drugs is more common among obese patients than among lean patients. The case we describe and the observations we report suggest that refractoriness among obese hypertensives is frequently caused by obstructive sleep apnea and/or inappropriately high plasma aldosterone levels. In other words, obese hypertensives may have sleep apnea, obese hypertensives without sleep apnea may have inappropriately elevated levels of plasma aldosterone, and a surprising...
233 Citations Source Cite
Published on Jan 1, 2004in Chinese Medical Journal 1.55
ZHANGXi-long9
Estimated H-index: 9
,
Kai-Sheng Yin5
Estimated H-index: 5
+ 2 AuthorsYu Yang3
Estimated H-index: 3
Background Adiponectin, secreted by adipocytes, has been found to be associated with diabetes, obesity and some cardiovascular diseases. Obstructive sleep apnea hypopnea syndrome (OSAHS) is also closely related to obesityand easily complicated with diabetes and some cardiovascular diseases. This study was carried out to explore the change of serum adiponectin level in patients with OSAHS. Methods Polysomnography was performed in 71 patients with OSAHS (OSAHS group) and 26 simple obese controls (...
22 Citations
Published on Jan 1, 2004in Clinical Endocrinology 2.90
Fabio Lanfranco26
Estimated H-index: 26
(UNITO: University of Turin),
L. Gianotti31
Estimated H-index: 31
(UNITO: University of Turin)
+ 6 AuthorsMauro Maccario38
Estimated H-index: 38
(UNITO: University of Turin)
Summary objective Obstructive sleep apnoea syndrome (OSAS) is strongly associated with obesity (OB) and is characterized by several changes in endocrine functions, e.g. GH/IGF-I axis, adrenal and thyroid activity. It is still unclear whether these alterations simply reflect overweight or include peculiar hypoxia-induced hormonal alterations. Hormonal evaluations have been generally performed in basal conditions but we have recently reported that OSAS is characterized by a more severe reduction o...
42 Citations Source Cite
Published on Oct 1, 2003in Biological Research For Nursing 1.51
Eileen R. Chasens21
Estimated H-index: 21
(UPenn: University of Pennsylvania),
Terri E. Weaver35
Estimated H-index: 35
(UPenn: University of Pennsylvania),
Mary Grace Umlauf17
Estimated H-index: 17
(UPenn: University of Pennsylvania)
The science of sleep is in early stages of development, and the biochemical consequences of obstructive sleep apnea (OSA) are slowly being identified. Only recently have investigators begun to identify the commonalities and interaction between OSA and insulin resistance, the underlying pathology of type 2 diabetes. Obesity and increasing age play important parts in the natural history of both conditions, which frequently coexist. The purpose of this article is, first, to examine the extent and s...
24 Citations Source Cite
Published on Oct 1, 2003in The Journal of Physiology
Vsevolod Y. Polotsky39
Estimated H-index: 39
(Johns Hopkins University),
Jianguo Li19
Estimated H-index: 19
(Johns Hopkins University)
+ 4 AuthorsChristopher P. O'Donnell37
Estimated H-index: 37
(Johns Hopkins University)
Obstructive sleep apnoea, a syndrome that leads to recurrent intermittent hypoxia, is associated with insulin resistance in obese individuals, but the mechanisms underlying this association remain unknown. We utilized a mouse model to examine the effects of intermittent hypoxia on insulin resistance in lean C57BL/6J mice and leptin-deficient obese (C57BL/6J−Lepob) mice. In lean mice, exposure to intermittent hypoxia for 5 days (short term) resulted in a decrease in fasting blood glucose levels (...
297 Citations Source Cite
Published on Sep 1, 2003in Clinical Endocrinology 2.90
Francesco Tassone18
Estimated H-index: 18
(UNITO: University of Turin),
Fabio Lanfranco26
Estimated H-index: 26
(UNITO: University of Turin)
+ 7 AuthorsMauro Maccario38
Estimated H-index: 38
(UNITO: University of Turin)
Summary objectives Obstructive sleep apnoea syndrome (OSAS) is strongly associated with obesity and characterized by endocrine and metabolic changes including impairment of insulin sensitivity. The aim of this study was to further clarify the insulin dynamics and glucose metabolism in this condition. design, patients and measurements We studied 30 obese patients with OSAS [OSA, 21 males, 9 females; age, mean ± SEM: 53·1 ± 1·7 years; body mass index (BMI): 38·6 ± 1·1 kg/m2; waist-to-hip ratio (WH...
80 Citations Source Cite
Published on Jul 1, 2003in Respiratory Physiology & Neurobiology 1.58
Naresh M. Punjabi49
Estimated H-index: 49
(Johns Hopkins University),
Murtuza M. Ahmed1
Estimated H-index: 1
(Johns Hopkins University)
+ 2 AuthorsChristopher P. O'Donnell37
Estimated H-index: 37
(Johns Hopkins University)
Abstract Sleep-disordered breathing (SDB) is a common condition with prevalence estimates of 2–4% in the general population. Epidemiological data suggest that SDB is an independent risk factor for cardiovascular disease. Glucose intolerance and insulin resistance are also well-recognized risk factors for the development of cardiovascular disease. A number of recent clinic-based studies suggest that, independent of obesity, SDB may adversely affect glucose tolerance and insulin sensitivity. The p...
232 Citations Source Cite
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