Efficacy of Tie2 Receptor Antagonism in Angiosarcoma
Abstract
Angiosarcomas are malignant endothelial cell tumors with few effective systemic treatments. Despite a unique endothelial origin, molecular candidates for targeted therapeutic intervention have been elusive. In this study, we explored the tunica internal endothelial cell kinase 2 (Tie2) receptor as a potential therapeutic target in angiosarcoma. Human angiosarcomas from diverse sites were shown to be universally immunoreactive for Tie2. Tie2 and...
Paper Details
Title
Efficacy of Tie2 Receptor Antagonism in Angiosarcoma
Published Date
Feb 1, 2012
Journal
Volume
14
Issue
2
Pages
131 - IN3
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