The Aging Adipose Organ: Lipid Redistribution, Inflammation, and Cellular Senescence
Published on Jan 1, 2014
· DOI :10.1007/978-1-62703-770-9_5
White adipose tissue (WAT) is an immensely plastic organ that plays a vital role in regulating metabolic homeostasis and systemic inflammation. Advancing age mitigates the dynamic nature of WAT which promotes the manifestation of several lipodystrophic-associated comorbidities. Inflammation and the accumulation of senescence cells likely play a key role in this process by inhibiting adipogenesis. The reduction of WAT functional capacity with aging and the role that inflammation and cellular senescence may play in this process will be explored throughout this review.