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Cited By374
Published on Dec 1, 2000
Gregory J. Welk48
Estimated H-index: 48
,
Steven N. Blair136
Estimated H-index: 136
37 Citations
Published on Jan 1, 2005
Lalita Khaodhiar19
Estimated H-index: 19
(Beth Israel Deaconess Medical Center),
George L. Blackburn69
Estimated H-index: 69
(Beth Israel Deaconess Medical Center)
Overweight and obesity have become epidemic in the United States and worldwide (1). Data from the National Center for Health Statistics indicate that the prevalence of obesity, defined as a body mass index (BMI) of 30 kg/m2 or more, increased from 12.8%in the years from 1976 to 1980, to 22.5% in the 1988 to1994 interval, to 30% in the 1999 and 2000 interval. Approximately 31% of US adults, about 59 million people, are considered obese, and more than 64% meet the criterion for overweight (BMI ≥25...
3 Citations Source Cite
Published on Jan 1, 1997in Journal of Thrombosis and Thrombolysis 2.62
Paul Chan11
Estimated H-index: 11
,
Tsuei Yuan Huang1
Estimated H-index: 1
+ 2 AuthorsChung Wen Tsai3
Estimated H-index: 3
Objectives: To investigate a possible relationship between hypertriglyceridemia and the coagulation system, a Cardiovascular Risk Factor Two-township Study was conducted in Taiwan. Design: A case-control study. This longitudinal, prospective study focused on the evolution of cardiovascular disease risk factors with emphasis on haemostatic factors. Subjects: Hypertriglyceridemic subjects (triglyceride <2.26 mmoll+1, n = 327) and age-matched normal controls from a population screening program. Mai...
9 Citations Source Cite
Nathaniel F. Watson28
Estimated H-index: 28
(University of Washington),
Dedra Buchwald53
Estimated H-index: 53
(University of Washington)
+ 2 AuthorsJack Goldberg48
Estimated H-index: 48
(University of Washington)
The advent of artificial lighting, shift work, television, the internet, and a 24-hour economy have all curtailed sleep times. As a result, sleep deprivation has reached epidemic proportions in our society, with ∼25% of the population regularly obtaining insufficient sleep to maintain normal alertness.1,2 Although the optimal amount of sleep for humans is unknown, we now sleep 1.5 h/night less than we did in 1910.3 In the 2002 National Sleep Foundation Sleep in America Poll, 39% of adults report...
57 Citations
Published on Jan 1, 2006in Nutrition Clinique Et Metabolisme 0.20
Luc Tappy52
Estimated H-index: 52
Published on Jan 1, 2009
Renato Pasquali3
Estimated H-index: 3
,
Alessandra Gambineri4
Estimated H-index: 4
There are many differences between the sexes in the susceptibility and the development of chronic metabolic and cardiovascular diseases, which may be partly explained by the disparate alterations of androgen balance particularly in the presence of obesity. Notably, available studies support the concept that the prevalence of insulin resistance, the metabolic syndrome, type 2 diabetes, and cardiovascular pathologies is different between the sexes. With respect to women, it is particularly evident...
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Published on Jan 1, 2009in Hormones, brain and behavior
Jill E. Schneider24
Estimated H-index: 24
(Lehigh University),
A.G. Watts1
Estimated H-index: 1
Gonadal hormones have profound effects on energy metabolism. Energy metabolism, in turn, controls the synthesis and secretion of the sex hormones. In addition to having reversible effects on energy metabolism in adults, sex hormones in utero set developmental events in motion that determine sexually dimorphic, lifelong patterns of body fat distribution. These patterns of body fat distribution are strongly associated with the prevalence of disease and mortality. To understand obesity-associated d...
6 Citations Source Cite
Published on Jan 1, 2012
Alain Veilleux13
Estimated H-index: 13
(Laval University),
André Tchernof48
Estimated H-index: 48
(Laval University)
Although obesity is an important determinant of metabolic disease, specific accumulation of visceral fat is strongly and independently associated with important metabolic alterations such as insulin resistance, hypertension, and dyslipidemia. A marked sex dimorphism and large interindividual variations are observed in fat distribution, and excess accumulation of visceral fat is a strong predictor of cardiometabolic risk in both sexes. However, adipose tissue cellularity and function are distinct...
7 Citations Source Cite
Published on Jan 1, 2013
Réjeanne Gougeon20
Estimated H-index: 20
(McGill University)
Population studies show an increased risk for diabetes with obesity, notably abdominal obesity. This risk is further aggravated by sedentary lifestyle and exposure to undernutrition in utero. Maternal obesity also alters fetal growth and development, leading to a larger baby prone to diabetes in adulthood. It is recommended to avoid excessive weight gains in pregnancy. The best predictor of type 2 diabetes in obesity is a concurrent insulin resistance and associated hyperinsulinemia with decreas...
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Leanne R. De Souza7
Estimated H-index: 7
(University of Toronto),
Eva Kogan1
Estimated H-index: 1
(St. Michael's Hospital)
+ 5 AuthorsJoel G. Ray44
Estimated H-index: 44
Abstract Background High pre-pregnancy body mass index is a known risk factor for gestational diabetes mellitus, but the contribution of abdominal adiposity to insulin resistance (IR) in pregnancy is not well understood. We assessed the association between abdominal adiposity in early pregnancy and IR. Methods We completed a prospective cohort study of 79 pregnant women. Visceral adipose tissue (VAT) depth was measured by ultrasonography at 11 to 14weeks' gestation, at the time of routine fetal ...
10 Citations Source Cite
View next paperBanting lecture 1988. Role of insulin resistance in human disease.