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Abdominal obesity as important component of insulin-resistance syndrome.

Published on Jan 1, 1993in Nutrition 3.73
Després Jp1
Estimated H-index: 1
Abstract
The regional distribution of body fat has been identified as a significant risk factor for the development of noninsulin-dependent diabetes mellitus and cardiovascular disease (CVD). Several studies that have investigated the potential associations between topographic features of adipose tissue and indices reflecting carbohydrate and lipid metabolism have reported significant associations between abdominal fat deposition and metabolic complications. The development of computed tomography as a means to precisely measure the amount of subcutaneous and deep adipose tissue at any site of the body has shown that determination of the level of visceral adipose tissue is a critical measurement to perform in the assessment of the health hazards of obesity. Studies that we have conducted in premenopausal women have clearly shown that the level of visceral adipose tissue is the best correlate of lipoprotein ratios used to estimate the risk of CVD. We have also reported that a high level of visceral adipose tissue is associated with a deterioration of glucose tolerance and that the relationship between visceral fat deposition and glucose tolerance remains significant after controlling for the level of total-body fat. Because significant interrelationships were observed between abdominal visceral obesity, insulin resistance, and dyslipoproteinemias in obese women, it is suggested that visceral obesity is an important component of the insulin-resistance syndrome (syndrome X) that has been previously described. This cluster of morphological, hormonal, and metabolic alterations observed in abdominal obesity may have substantial implications for the treatment of this condition.
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Published on May 1, 2019in Joint Bone Spine 3.30
Yanlin Wei (Zhengzhou University), Nannan Xia (Zhengzhou University)+ 5 AuthorsLei Yang (Zhengzhou University)
Abstract Objective Retinol-binding protein 4 (RBP4), systemic inflammation and insulin resistance (IR) are linked, yet the determinants of RBP4 and its impact on IR in rheumatoid arthritis (RA) are incompletely understood. The aim of this study was to explore the prevalence of IR in RA and investigate whether the serum levels of RBP4 were associated with IR in patients with RA. Methods In this study, 403 individuals with newly diagnosed and untreated RA were consecutively recruited. We calculate...
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Published on Apr 1, 2019in International Journal of Obesity 5.16
Inge Verkouter1
Estimated H-index: 1
(Leiden University Medical Center),
Raymond Noordam15
Estimated H-index: 15
(Leiden University Medical Center)
+ 4 AuthorsMutsert de Renee26
Estimated H-index: 26
(Leiden University Medical Center)
We aimed to investigate the associations between weight change during adulthood and the amount of abdominal subcutaneous fat, visceral fat, and liver fat at middle age. The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort of 6671 middle-aged men and women. We calculated the percentage of weight change during adulthood based on body weight at middle age and recalled body weight at age 20. Abdominal subcutaneous and visceral adipose tissue were assessed by magnetic reso...
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Published on Mar 1, 2019in American Journal of Lifestyle Medicine
James M. Rippe26
Estimated H-index: 26
Daily habits and actions powerfully affect the risk of cardiovascular disease (CVD), in general, and coronary heart disease, in particular. Regular physical activity, sound nutrition, weight management, and not smoking cigarettes have all been demonstrated to significantly reduce the risk of CVD. In 2 large cohort studies a reduction of risk of CVD of >80% and diabetes >90% were demonstrated in individuals who followed a cluster of these lifestyle practices. The study of the impact of lifestyle ...
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Published on Mar 1, 2019in Journal of Ultrasound in Medicine 1.53
Shiri Shinar1
Estimated H-index: 1
(St. Michael's Hospital),
Howard Berger18
Estimated H-index: 18
(St. Michael's Hospital)
+ 1 AuthorsJoel G. Ray49
Estimated H-index: 49
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Published on Feb 1, 2019in Diabetologia 6.02
Seung Mi Lee25
Estimated H-index: 25
(Seoul National University),
Soo Heon Kwak23
Estimated H-index: 23
(Seoul National University)
+ 15 AuthorsSae Kyung Joo7
Estimated H-index: 7
(Seoul National University)
Aims/hypothesis Although there is substantial evidence that non-alcoholic fatty liver disease (NAFLD) is associated with impaired glucose homeostasis, the clinical significance of NAFLD in pregnant women has not been well determined. This study investigates the relationship between NAFLD in the first trimester and the subsequent development of gestational diabetes mellitus (GDM).
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Published on Feb 1, 2019in Journal of International Medical Research 1.02
Ying Zhao3
Estimated H-index: 3
(Second Military Medical University),
Li-Juan Xiu6
Estimated H-index: 6
(Second Military Medical University)
+ 3 AuthorsPin-Kang Wei9
Estimated H-index: 9
(Second Military Medical University)
ObjectiveThis study was performed to assess the influence of obesity on colorectal cancer (CRC) and investigate the efficacy of Xiaotan Tongfu (XTTF) decoction to CRC treatment.MethodsBALB/C mice were used to establish an obesity-associated CRC model by a high-fat diet and tumor implantation. The tumors were harvested from mice inoculated with CT26 cell suspension. Body weight, liver weight, hepatic metastasis, and histological changes were observed. Immunohistochemical analysis and real-time po...
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Published on Dec 1, 2018in Food Science and Biotechnology 0.79
Young Mi Park3
Estimated H-index: 3
(Andong National University),
Jee-In Kim1
Estimated H-index: 1
(Kyungpook National University)
+ 5 AuthorsEul-Won Seo2
Estimated H-index: 2
(Andong National University)
Obesity is generally caused by quantitative changes in adipocyte differentiation and fat metabolism. Only a few studies have been determined the effect of red beans extract on obesity and plasma cholesterol concentration. We have been studied the functional activities of red-bean extracts including anti-oxidative effect against DNA and cell damages. Histological study including micro CT analysis showed that the accumulation of fat in hepatocytes and intestines was significantly decreased in red ...
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Published on Dec 1, 2018in BMC Obesity
Steven Ndugwa Kabwama4
Estimated H-index: 4
(Makerere University),
Barbara Eva Kirunda3
Estimated H-index: 3
(Makerere University)
+ 3 AuthorsDavid Guwatudde18
Estimated H-index: 18
(Makerere University)
Background Overweight and obesity are associated with health complications the gravity of which, vary with the regional deposition of the excess fat. The Body Mass Index (BMI) is often used to measure obesity although is an inferior predictor of cardiovascular disease risk mortality and morbidity compared with measures of abdominal obesity. We analyzed data from Uganda’s 2014 World Health Organization (WHO) STEPwise approach to surveillance of Non-communicable diseases (NCDs) survey to estimate ...
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Published on Nov 1, 2018in Nutrition 3.73
Xinyan Bi3
Estimated H-index: 3
(Agency for Science, Technology and Research),
Yi Ting Loo (Agency for Science, Technology and Research), Christiani Jeyakumar Henry27
Estimated H-index: 27
(Agency for Science, Technology and Research)
Abstract Objectives Insulin resistance (IR) is important in the pathogenesis of diabetes, the prevalence of which has become a major public health threat in Asia. The aim of this study was to use ultrasound measurements of abdominal fat thickness to predict IR and low high-density lipoprotein cholesterol (HDL-C) levels among Singaporean adults. Methods A total of 399 healthy Singaporeans (mean age 36.7 ± 14.3 y; 43.4% men) took part in this study. Preperitoneal fat thickness (PFT) and subcutaneo...
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Published on Oct 4, 2018in JCI insight
Ritwik Datta5
Estimated H-index: 5
,
Michael J. Podolsky2
Estimated H-index: 2
,
Kamran Atabai15
Estimated H-index: 15
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