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The Edrophonium Test

Published on Mar 1, 2003in Seminars in Neurology1.473
· DOI :10.1055/s-2003-40755
Robert M. Pascuzzi7
Estimated H-index: 7
Abstract
Cholinesterase inhibitors (CEIs) have been known to improve strength in patients with myasthenia gravis (MG) since the 1930s, and have been used as a diagnostic test since the early 1950s. The following review summarizes the history of edrophonium usage in myasthenia gravis, reviews the literature with regard to the method of performing the edrophonium test, and discusses the available information regarding sensitivity and specificity of the test with respect to diagnosis of MG.
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Cited By58
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Resumen La miastenia gravis (MG) es la enfermedad de la union neuromuscular mas frecuente. Se trata de un trastorno adquirido de base autoinmune, en el que se detectan diferentes anticuerpos contra elementos del receptor muscular postsinaptico. Los sintomas iniciales suelen aparecer en un grupo muscular aislado, preferentemente en la musculatura ocular con aparicion de ptosis y diplopia. Posteriormente, los sintomas progresan con afectacion muscular generalizada, apareciendo una afectacion bulba...
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#1Lorenzo MaggiH-Index: 21
#2Pia BernasconiH-Index: 31
Last. Renato MantegazzaH-Index: 44
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Congenital myasthenic syndromes (CMS) are genetic disorders due to mutations in genes encoding proteins involved in the neuromuscular junction structure and function. CMS usually present in young children, but perinatal and adult onset has been reported. Clinical presentation is highly heterogeneous, ranging from mild symptoms to severe manifestations, sometimes with life-threatening respiratory episodes, especially in the first decade of life. Although considered rare, CMS are probably underest...
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#1Swarna Rajagopalan (WVU: West Virginia University)
#2Sanam Baghshomali (WVU: West Virginia University)
Last. Atul A. Kalanuria (HUP: Hospital of the University of Pennsylvania)
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Neuromuscular emergencies are a distinct group of acute neurological diseases with distinct characteristic presentations. Patients who suffer from this group of diseases are at immediate risk of losing protection of their native airway as well as aspirating orogastric contents. This is secondary to weakness of the muscles of the oropharynx and respiratory muscles. Although some neuromuscular emergencies such as myasthenia gravis or Guillain-Barre syndrome are well understood, others such as crit...
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#1Amanda C. Guidon (Harvard University)H-Index: 6
This chapter reviews the latest developments in the epidemiology, pathophysiology, diagnosis, and treatment of autoimmune myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS). The biologic and phenotypic heterogeneity of MG is highlighted, and the effect of this heterogeneity on disease course, choice of treatment, and response to therapy is emphasized. Discussion of myasthenia subtypes and additional references for further reading are provided. The approach to diagnosis and manag...
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#1Sun Im (Catholic University of Korea)H-Index: 10
#2Sonja Suntrup-Krueger (WWU: University of Münster)H-Index: 7
Last. Tobias Warnecke (WWU: University of Münster)H-Index: 24
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Resumen La miastenia gravis es el trastorno mas comun dentro de las enfermedades que afectan a la transmision neuromuscular. Actualmente es uno de los trastornos autoinmunes mejor definidos y entendidos. Esta se caracteriza por debilidad y fatiga de forma fluctuante y en combinacion variable de los musculos oculares, funciones bulbares, de las extremidades y de los musculos respiratorios. Estos sintomas son el resultado de un ataque inmunologico contra la membrana postsinaptica de la union neuro...
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#1Shinichi MatsumotoH-Index: 4
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The diagnosis of Myasthenia gravis (MG) is chiefly based on clinical symptoms and neurological examination coupled with serological testing for the presence of auto-antibodies, electrodiagnostic studies consisting of repetitive nerve stimulation test (RNST) and single fiber electromyography (SFEMG) and pharmacologic tests such as the edrophonium test. The ice pack test, based on the scientific principle that cooling improves neuromuscular transmission in Myasthenia gravis (MG), is a low cost, se...
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#1Wael Richeh (LSU Health Sciences Center New Orleans)
#2John D. Engand (LSU Health Sciences Center New Orleans)
Last. Richard M. Paddison (LSU Health Sciences Center New Orleans)
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Myasthenia gravis is an autoimmune neuromuscular junction disorder. This uncommon disease is characterized by fluctuating muscle weakness that worsens with exertion and improves with rest. The initial presentation is consistent with involvement of the extrinsic ocular muscle. The myasthenia usually progresses to involve other bulbar muscles and limb musculature, resulting in generalized myasthenia gravis. Although the etiology of the disorder remains unknown, the role of circulating antibodies d...
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