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In Vivo Magnetic Resonance Spectroscopy in Breast Cancer

Published on Jan 1, 2008
· DOI :10.1007/1-4020-3910-7_120
Uma Sharma23
Estimated H-index: 23
(AIIMS: All India Institute of Medical Sciences),
N. R. Jagannathan5
Estimated H-index: 5
(AIIMS: All India Institute of Medical Sciences)
Abstract
Abbreviations: MR, magnetic resonance; MRI, magnetic resonance imaging; MRS, magnetic resonance spectroscopy; 1H MRS, proton magnetic resonance spectroscopy; 31P MRS, phosphorus magnetic resonance spectroscopy; CE-MRI, contrast-enhanced magnetic resonance imaging; VOI, volume of interest; CSI, chemical shift imaging; MRSI, magnetic resonance spectroscopic imaging; STEAM, stimulated echo acquisition mode; PRESS, point resolved spectroscopy; CHESS, chemical shift selective; W–F, water-to-fat ratio; PME, phosphomonoester; PDE, phosphodiester; PCr, phosphocreatine; SV, single-voxel.
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  • Citations (5)
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Cited By5
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#1Uma Sharma (AIIMS: All India Institute of Medical Sciences)H-Index: 23
#2Hyeon-Man Baek (UTSW: University of Texas Southwestern Medical Center)H-Index: 17
Last. Naranamangalam R. Jagannathan (AIIMS: All India Institute of Medical Sciences)H-Index: 33
view all 4 authors...
MRI and in vivo MRS have rapidly evolved as sensitive tools for diagnosis and therapeutic monitoring in cancer research. In vivo MRS provides information on tumor metabolism, which is clinically valuable in the diagnosis and assessment of tumor response to therapy for the management of women with breast diseases. Several centers complement breast MRI studies with 1H MRS to improve the specificity of diagnosis. Malignant breast tissues show elevated water-to-fat ratio and choline-containing compo...
41 CitationsSource
#1Robyn L. Birdwell (Partners HealthCare)H-Index: 35
Last. J. Dirk IglehartH-Index: 40
view all 3 authors...
OBJECTIVE. Personalized health care centers around the concept that each tumor and its host environment is unique; optimal treatment and expected response for any given woman presenting with a newly diagnosed breast cancer differ from the care and response of other women.CONCLUSION. As more is understood about the molecular subtypes of breast cancer and as development of targeted therapies progresses, the possibility of earlier treatment response assessment and even improved detection will be re...
10 CitationsSource
#1Peter StanwellH-Index: 28
#2Carolyn E. Mountford (Harvard University)H-Index: 41
In vivo proton magnetic resonance (MR) spectroscopy (hydrogen 1 spectroscopy) provides useful information about the pathology of breast lesions by the measurement of diagnostic chemicals visible on the MR timescale. Spectroscopic measurements may be obtained following contrast-enhanced MR imaging by applying a point-resolved spatially localized spectroscopy sequence. The observation of resonances at discrete spectral frequencies allows an accurate diagnosis. In spectra obtained in vivo in malign...
57 CitationsSource
#1Peter StanwellH-Index: 28
In vivo proton magnetic resonance (MR) spectroscopy (hydrogen 1 spectroscopy) provides useful information about the pathology of breast lesions by the measurement of diagnostic chemicals visible on the MR timescale. Spectroscopic measurements may be obtained following contrast-enhanced MR imaging by applying a point-resolved spatially localized spectroscopy sequence. The observation of resonances at discrete spectral frequencies allows an accurate diagnosis. In spectra obtained in vivo in malign...