Mitochondrial OGG1 protects against PM2.5-induced oxidative DNA damage in BEAS-2B cells

The enzyme 8-oxoguanine glycosylase 1 (OGG1) has been shown to be involved in the repair of oxidative DNA damage. However, the effect of OGG1 on oxidative DNA damage caused by particulate matter 2.5 (PM2.5) is unknown. Herein, we demonstrated that OGG1 could inhibit the generation of ROS and alleviate mitochondrial dysfunction and increased the expression of IL-1β caused by PM2.5. The dichlorodihydrofluorescein diacetate (DCFH-DA) staining and...