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Type 2 responses at the interface between immunity and fat metabolism.

Published on Oct 1, 2015in Current Opinion in Immunology7.67
· DOI :10.1016/j.coi.2015.07.003
Justin I. Odegaard26
Estimated H-index: 26
(UCSF: University of California, San Francisco),
Ajay Chawla37
Estimated H-index: 37
(UCSF: University of California, San Francisco)
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Abstract
Adipose tissue resident leukocytes are often cast solely as the effectors of obesity and its attendant pathologies; however, recent observations have demonstrated that these cells support and effect ‘healthy’ physiologic function as well as pathologic dysfunction. Importantly, these two disparate outcomes are underpinned by similarly disparate immune programs; type 2 responses instruct and promote metabolic normalcy, while type 1 responses drive tissue dysfunction. In this Review, we summarize the literature regarding type 2 immunity's role in adipose tissue physiology and allude to its potential therapeutic implications.
  • References (60)
  • Citations (26)
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References60
Newest
#1Dicky L. Tahapary (UI: University of Indonesia)H-Index: 4
#2Karin de Ruiter (LUMC: Leiden University Medical Center)H-Index: 2
Last.Jeanine J. Houwing-Duistermaat (LUMC: Leiden University Medical Center)H-Index: 46
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#1Laurence E. Cheng (UCSF: University of California, San Francisco)H-Index: 14
#2Richard M. Locksley (UCSF: University of California, San Francisco)H-Index: 89
#1Min-Woo Lee (UCSF: University of California, San Francisco)H-Index: 2
#2Justin I. Odegaard (UCSF: University of California, San Francisco)H-Index: 26
Last.Ajay Chawla (UCSF: University of California, San Francisco)H-Index: 37
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#1Corinne Cayrol (CNRS: Centre national de la recherche scientifique)H-Index: 15
#2Jean-Philippe Girard (CNRS: Centre national de la recherche scientifique)H-Index: 47
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