Type 2 responses at the interface between immunity and fat metabolism.

Published on Oct 1, 2015in Current Opinion in Immunology7.667
· DOI :10.1016/j.coi.2015.07.003
Justin I. Odegaard28
Estimated H-index: 28
(UCSF: University of California, San Francisco),
Ajay Chawla38
Estimated H-index: 38
(UCSF: University of California, San Francisco)
Adipose tissue resident leukocytes are often cast solely as the effectors of obesity and its attendant pathologies; however, recent observations have demonstrated that these cells support and effect ‘healthy’ physiologic function as well as pathologic dysfunction. Importantly, these two disparate outcomes are underpinned by similarly disparate immune programs; type 2 responses instruct and promote metabolic normalcy, while type 1 responses drive tissue dysfunction. In this Review, we summarize the literature regarding type 2 immunity's role in adipose tissue physiology and allude to its potential therapeutic implications.
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