Estetrol, Molecular Chaperones, and the Epigenetics of Longevity and Cancer Resistance

Evidence is given that replicative senescence—possibly as organismal aging—constitutes epigenetic phenomena, counteracted by homeostatic factors such as, e.g., the molecular chaperones, which are housekeeping molecules essential for the folding, repair, and transport of proteins, RNA, and DNA. Weakening of the chaperone defense with age probably contributes to the frailty in senescence. The present review presents evidence that the human fetal...