Manipulation of lysozyme phase behavior by additives as function of conformational stability.

Volume: 494, Issue: 1, Pages: 370 - 380
Published: Oct 15, 2015
Abstract
Undesired protein aggregation in general and non-native protein aggregation in particular need to be inhibited during bio-pharmaceutical processing to ensure patient safety and to maintain product activity. In this work the potency of different additives, namely glycerol, PEG 1000, and glycine, to prevent lysozyme aggregation and selectively manipulate lysozyme phase behavior was investigated. The results revealed a strong pH dependency of the...
Paper Details
Title
Manipulation of lysozyme phase behavior by additives as function of conformational stability.
Published Date
Oct 15, 2015
Volume
494
Issue
1
Pages
370 - 380
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