HIV-1 Associated Dementia: Clinical Features and Pathogenesis

HIV-1 infection is characterized by multiple neurological syndromes occurring at all stages of infection. HIV-1-associated dementia, however, is the most devastating CNS consequence of AIDS because of its poor prognosis and functional impairment. A clinical triad of progressive cognitive decline, motor dysfunction, and behavioural abnormalities typifies this subcortical dementia which eventually affects 15 to 20% of AIDS patients. Neuroimaging,...