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Amir H. Meghdadi8
Estimated H-index: 8
,
Djordje Popovic11
Estimated H-index: 11
+ 3 AuthorsAjay Verma9
Estimated H-index: 9
Objective: To demonstrate the utility of rheoencephalography (REG) for measuring cerebral blood flow and fluid dynamics during different stages of sleep. Methods: Anteroposterior cranial electrical impedance was measured with concurrent polysomnography in a group of healthy subjects during sleep. Transcranial electrical impedance was characterized by measuring the peak-to-trough and envelope of the filtered pulsative REG signal as well as its frequency. The sensitivity of the REG amplitude to ch...
Published on Nov 29, 2017in Frontiers in Molecular Neuroscience 3.72
Jingzhu Zhang3
Estimated H-index: 3
(PRC: China Medical University (PRC)),
Zhipeng Zhan2
Estimated H-index: 2
(PRC: China Medical University (PRC))
+ 5 AuthorsLi An2
Estimated H-index: 2
(PRC: China Medical University (PRC))
The impairment of Aβ clearance in the brain plays a causative role in Alzheimer’s disease. Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain. AQP4 polarity can be influenced by the ratio of two AQP4 isoforms M1 and M23 (AQP4-M1/M23), however, it is unknown whether the ratio of AQP4-M1/M23 changes in Alzheimer’s disease. Histone deacetylase3 has been reported to be significantly increased in Alzheimer’s disease brain. Moreover, evidence indicated that microRNA-130a ...
Published on Nov 1, 2017in Journal of Chemical Neuroanatomy 2.36
Parmi Patel1
Estimated H-index: 1
(NU: Nirma University of Science and Technology),
Jigna Shah5
Estimated H-index: 5
(NU: Nirma University of Science and Technology)
Abstract Amyloid beta (Aβ) deposition is considered to be one of the primary reason to trigger Alzheimer’s disease (AD). Literature clearly suggests decline in Aβ clearance to be accountable for progression of late onset AD as compared to augmented Aβ production. There may be several pathways for Aβ clearance out of which one of the major pathway is the vascular-mediated removal of Aβ from the brain across the blood-brain barrier (BBB) via efflux pumps or receptors. Among Aβ scavenger receptors,...
Published on Jan 1, 2017
Akhlaq A. Farooqui46
Estimated H-index: 46
(OSU: Ohio State University)
Alzheimer's disease (AD) is an age-associated neurodegenerative disorder that causes severe impairment of cognitive function, leading to a drastic decline in the quality of life. Neuropathological features of AD include the accumulation of β-amyloid (Aβ) and deposition of extracellular senile plaques and accumulation of intraneuronal tangles that consist of aggregated and hyperphosphorylated Tau protein. According to the Aβ cascade hypothesis of AD, the overproduction of Aβ is a consequence of t...
Published on Aug 1, 2015in Nature Reviews Neurology 21.16
Jenna M. Tarasoff-Conway2
Estimated H-index: 2
,
Roxana O. Carare20
Estimated H-index: 20
+ 13 AuthorsBerislav V. Zlokovic87
Estimated H-index: 87
The elimination of amyloid-β (Aβ) from the brain is already impaired at the prodromal stage of Alzheimer disease (AD), so restoration of the clearance systems of the brain might delay the onset of AD. This Review provides a comprehensive update on the brain's clearance systems, including the recent discoveries of the glymphatic system and meningeal lymphatic vessels—findings that have important implications for understanding the disrupted elimination of toxic proteins in AD.
Published on Jan 1, 2015in Frontiers in Aging Neuroscience 3.63
Anita Ramanathan6
Estimated H-index: 6
(SC: University of Southern California),
Amy R. Nelson12
Estimated H-index: 12
(SC: University of Southern California)
+ 1 AuthorsBerislav V. Zlokovic87
Estimated H-index: 87
(SC: University of Southern California)
Amyloid beta (Aβ) homeostasis in the brain is governed by its production and clearance mechanisms. An imbalance in this homeostasis results in pathological accumulations of cerebral Aβ, a characteristic of Alzheimer’s disease (AD). While Aβ may be cleared by several physiological mechanisms, a major route of Aβ clearance is the vascular-mediated removal of Aβ from the brain across the blood-brain barrier (BBB). Here, we discuss the role of the predominant Aβ clearance protein—low-density lipopro...
Published on Jan 1, 2014in Folia Neuropathologica 1.16
Adrian Andrzej Chrobak5
Estimated H-index: 5
,
Dariusz Adamek15
Estimated H-index: 15
Abstract A seminal article of Takahashi et al. reporting concomitant accumulation of cellular prion protein (PrP c ) and β -amy-loid (A β ) in dystrophic neurites, within neuritic plaques raised an exciting issue that is important for our under-standing of mechanisms of neurodegeneration. The mentioned authors interpreted their findings rather cautiously, however since the time of their publication, several reports representing different approaches and methods have seemed to indicate that both p...
Published on Jun 19, 2013in ACS Chemical Neuroscience 3.86
Alaa H. Abuznait9
Estimated H-index: 9
,
Hisham Qosa12
Estimated H-index: 12
+ 2 AuthorsAmal Kaddoumi26
Estimated H-index: 26
Oleocanthal, a phenolic component of extra-virgin olive oil, has been recently linked to reduced risk of Alzheimer’s disease (AD), a neurodegenerative disease that is characterized by accumulation of β-amyloid (Aβ) and tau proteins in the brain. However, the mechanism by which oleocanthal exerts its neuroprotective effect is still incompletely understood. Here, we provide in vitro and in vivo evidence for the potential of oleocanthal to enhance Aβ clearance from the brain via up-regulation of P-...
Published on Jan 1, 2013
Takaomi C. Saido76
Estimated H-index: 76
(Riken-BSI: RIKEN Brain Science Institute)
The conversion of what has been interpreted as “normal brain aging” to Alzheimer’s disease (AD) via transition states, i.e., preclinical AD and mild cognitive impairment, appears to be a continuous process caused primarily by aging-dependent accumulation of amyloid β peptide (Aβ) in the brain. This notion however gives us a hope that, by manipulating the Aβ levels in the brain, we may be able not only to prevent and cure the disease but also to partially control some very significant aspects of ...