SASH1 Is Involved in an Autosomal Dominant Lentiginous Phenotype

Skin pigmentation disorders are among the most recognizable human diseases, strongly impacting both health and quality of life. Lentigines are small, hyper-pigmented skin macules, histologically containing increased numbers of melanocytes, typically producing elevated amounts of melanin. Most lentigines are caused by UV radiation and appear with increasing age. However, lentigines can also be inherited in an autosomal dominant pattern; in these...