Abstract
Initial analysis of the expression profile of two NMDAR1 mRNA isoform subsets, NR1oxx and NR11xx, in discrete regions of human cerebral cortex was performed. The subsets are characterized by the absence or presence of a 21-amino acid N-terminal cassette. RT-PCR for NR1 isoforms was performed on total RNA preparations from spared and susceptible regions from pathologically confirmed Alzheimer disease (AD) cases and matched Controls. NR11xx...
Paper Details
Title
Excitotoxic neurodegeneration in Alzheimer's disease
Published Date
Jan 1, 2004
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History