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Frontiers in Neurology
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#1Yue-ye Wang (ZJU: Zhejiang University)
#2Keyao Zhou (WHU: Wuhan University)H-Index: 1
Last. Ke Yao (ZJU: Zhejiang University)
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Moyamoya disease (MMD) is a chronic cerebrovascular disease that is frequently resulting in intracranial ischemia or hemorrhage. Its concurrence with varying ophthalmic findings is relatively rare yet may lead to irreversible blindness. We performed a search and review of the literature to characterize the relevance of MMD (excluding moyamoya syndrome) and ophthalmic findings. As a result, a total of 38 articles identified from PubMed and Web of Science were included in this mini-review. Patient...
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#1Christian Lechner (Innsbruck Medical University)H-Index: 6
#2Markus Breu (Medical University of Vienna)H-Index: 2
Last. Kevin Rostasy (Boston Children's Hospital)H-Index: 41
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Background: Neuromyelitis optica spectrum disorders (NMOSD) are severe inflammatory demyelinating disorders of the central nervous system mainly characterized by recurrent episodes of uni- or bilateral optic neuritis (ON), transverse myelitis (TM) and brainstem syndromes (BS). The majority of adult patients has serum antibodies directed against the water channel protein aquaporin 4 (AQP4-abs). In paediatric patients, AQP4-abs are less, while antibodies against myelin oligodendrocyte glycoprotein...
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#1R Marques (University of León)
#2Henriette Thole (Novartis)
Last. Jose G. Ruiz de Morales (University of León)H-Index: 6
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Patient registries offer a powerful and practical means of real-world data collection system for rare diseases. Many guidelines have been released to standardize patient registries, though most of them do not address issues specific to rare disease patient registries. In November 2018, the European Medicines Agency (EMA) released a draft discussion paper on methodological and operational aspects of disease registries and made proposals on good registry practice (henceforth referred to as EMA gui...
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#1Steven Bentley (Griffith University)H-Index: 3
#2Suliman Khan (Griffith University)H-Index: 1
Last. Stephen A. Wood (Griffith University)H-Index: 28
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The study of consanguineous families has provided novel insights into genetic causes of monogenic parkinsonism. Here we present a family from the rural Khyber Pakhtunkhwa province, Pakistan, where three siblings were diagnosed with early-onset parkinsonism. Homozygosity mapping of two affected siblings and three unaffected family members identified two candidate autozygous loci segregating with disease, 8q24.12-8q24.13 and 9q31.2-q33.1. Whole exome sequence analysis identified a single rare homo...
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#1Shinya Tomari (University of Newcastle)
#2Parker Magin (University of Newcastle)H-Index: 22
Last. Valery L. Feigin (AUT: Auckland University of Technology)H-Index: 73
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Background: Transient ischemic attack (TIA) and minor stroke (TIAMS) are risk factors for stroke recurrence. Some TIAMS may be preventable by appropriate primary prevention. We aimed to recruit “possible-TIAMS” patients in the INternational comparison of Systems of care and patient outcomes In minor Stroke and TIA (INSIST) study. Methods: A prospective inception cohort study performed across 16 Hunter–Manning region, Australia, general practices in the catchment of one secondary-care acute neuro...
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#1Anna KamieniarzH-Index: 2
#2Justyna MichalskaH-Index: 2
Last. Grzegorz JurasH-Index: 8
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Background: People with Parkinson’s disease (PD) exhibit deficits in maintaining balance both during quiet standing and during walking, turning, standing up from sitting, and step initiation. Objective: The purpose of this study was to examine balance disorders during a transitional task under different conditions in participants with PD. Methods: The research was conducted on 15 PD-II (mild) and 15 PD-III (moderate) individuals (H&Y II-III stage) and 30 healthy elderly. The transitional task wa...
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#1Li Liu (HIT: Harbin Institute of Technology)H-Index: 1
#2Ping Yin (HIT: Harbin Institute of Technology)H-Index: 1
Last. Yafen Wei (HIT: Harbin Institute of Technology)H-Index: 1
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Stroke remains a leading cause of death and disability. The low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C ratio) ratio has been confirmed to be a predictor of stroke. However, few studies have assessed the prognostic impact of the LDL-C/HDL-C ratio for stroke patients. We aimed to investigate the relationship between the LDL-C/HDL-C ratio and the prognosis following stroke in Chinese patients. A total of 3410 patients who had experienced their first isc...
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#1Maurizio Bergamino (Barrow Neurological Institute)
#2Elizabeth G. Keeling (ASU: Arizona State University)
Last. Ryan R. Walsh (Barrow Neurological Institute)H-Index: 2
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Structural brain white matter (WM) changes such as axonal caliber, density, myelination, and orientation along with WM-dependent structural connectivity may be impacted early in Parkinson’s disease (PD). Diffusion MRI (dMRI) has been used extensively to understand such pathological WM changes, and the focus of this systematic review is to understand both the methods utilized and their corresponding results in the context of early-stage PD. Diffusion tensor imaging (DTI) is the most commonly util...
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#1Ziqi Guo (PolyU: Hong Kong Polytechnic University)
#2Qiuyang Qian (PolyU: Hong Kong Polytechnic University)H-Index: 2
Last. Yong-Ping Zheng (PolyU: Hong Kong Polytechnic University)H-Index: 35
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Background: Proximal compensation to the distal movements is commonly observed in the upper extremity (UE) in patients with chronic stroke. However, the cortical origin of this compensation has not been well understood. In this study, corticomuscular coherence (CMCoh) and electromyography (EMG) analysis were adopted to investigate corticomuscular coordinating mechanism of post-stroke compensatory activities of proximal UE in distal motions of the affected hands. Method: Fourteen chronic stroke s...
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