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Brain Research
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#1Bárbara Oliveira (Institute of Science and Technology Austria)
#2Aysan Çerağ Yahya (Institute of Science and Technology Austria)
Last.Gaia Novarino (Institute of Science and Technology Austria)H-Index: 8
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Abstract Until recently, a great amount of brain studies have been conducted in human post mortem tissues, cell lines and model organisms. These researches provided useful insights regarding cell-cell interactions occurring in the brain. However, such approaches suffer from technical limitations and inaccurate modeling of the tissue 3D cytoarchitecture. Importantly, they might lack a human genetic background essential for disease modeling. With the development of protocols to generate human cere...
#1Jordan Nadeau (Laval University)
#2Tara C. SmithH-Index: 22
Last.Denis Soulet (Laval University)H-Index: 16
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Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. It is typically associated with motor symptoms originating from the degeneration of nigrostriatal dopamine (DA) neurons. Early stages of PD have been associated with an alteration in DA production in intestinal DAergic neurons along with inflammation. Interestingly, decreased serum concentrations of ethanolamine plasmalogens (PlsEtn) have been reported in PD patients. Ethanolamine plasmalogens play a...
#1Nicholas H. Russell (MCV: VCU Medical Center)
#2Raiford T. Black (MCV: VCU Medical Center)H-Index: 1
Last.Linda L. Phillips (MCV: VCU Medical Center)H-Index: 22
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Abstract Traumatic brain injury (TBI) often presents with focal contusion and parenchymal bleeds, activating heme oxygenase (HO) to degrade released hemoglobin. Here we show that diffuse, midline fluid percussion injury causes time-dependent induction of HO-1 and iron binding proteins within both hemorrhagic neocortex and non-hemorrhagic hippocampus. Rats subjected to midline fluid percussion injury (FPI) survived 1-15d postinjury and tissue was collected for Western blot and immunohistochemical...
#1Afef Ouelhazi (UdeM: Université de Montréal)H-Index: 1
#2Vishal Bharmauria (York University)
Last.Stéphane Molotchnikoff (UdeM: Université de Montréal)H-Index: 19
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Abstract The plasticity of the adult brain is one of the most highly evolving areas of recent neuroscience research. It has been acknowledged that the visual cortex in adulthood can adapt and restructure the neuronal connections in response to a sensory experience or to an imposed input such as in adaptation or ocular deprivation protocols. In order to understand the basic cellular mechanisms of plasticity in the primary visual cortex (V1), we examined the effects of ketamine, a non-competitive,...
#1Carlos Henrique Rocha Catalão (USP: University of São Paulo)H-Index: 5
#2Anderson O. Souza (USP: University of São Paulo)H-Index: 3
Last.Luiza da Silva Lopes (USP: University of São Paulo)H-Index: 7
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Abstract In hydrocephalus, the progressive accumulation of cerebrospinal fluid (CSF) causes dilatation of the lateral ventricles affecting the third ventricle and diencephalic structures such as the hypothalamus. These structures play a key role in the regulation of several neurovegetative functions by the production of the hormones. Since endocrine disturbances are commonly observed in hydrocephalic children, we investigated the impact of progressive ventricular dilation on the hypothalamus of ...
#1Ray O. Bahado-Singh (Oakland University)H-Index: 27
#2Sangeetha Vishweswaraiah (Oakland University)
Last.Uppala Radhakrishna (Oakland University)H-Index: 3
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Abstract A great diversity of factors contribute to the pathogenesis of autism and autism spectrum disorder (ASD). Early detection is known to correlate with improved long term outcomes. There is therefore intense scientific interest in the pathogenesis of and early prediction of autism. Recent reports suggest that epigenetic alterations may play a vital role in disease pathophysiology. We conducted an epigenome-wide analysis of newborn leucocyte (blood spot) DNA in autism as defined at the time...
#1Ruixi Zhou (Sichuan University)
#2Yi Qu (Sichuan University)H-Index: 13
Last.Xihong Li (Sichuan University)H-Index: 6
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Abstract Sepsis has a high in clinic neonatal mortality. Moreover, a considerable number of children's brains remain affected even after the treatment of sepsis and it often leaves sequelae. Therefore, early intervention for sepsis is of considerable significance. Recent studies have shown that Club cell protein (CC16) is closely related to the p38 mitogen-activated protein kinase (MAPK) signaling pathway, which can regulate inflammation, oxidative stress, apoptosis, and autophagy during sepsis....
Abstract Brain organoids have rapidly become established as promising tools for studying both the normal embryonic development of the brain and the mechanistic roots of neurodevelopmental disorders. Most recent studies are based on brain organoids derived from human pluripotent stem cells (PSCs), as these are likely to be the best way to understand normal human development and disease. However, brain organoids grown from mouse cells still have a role to play. We discuss recent work showing how m...
#1Mami Nakanishi (Tottori University)H-Index: 2
#2Yasuhiro Watanabe (Tottori University)H-Index: 14
Last.Ritsuko Hanajima (Tottori University)H-Index: 38
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Abstract Stem cells offer great hope for the therapy of neurological disorders. Using a human artificial chromosome (HAC), we generated modified mesenchymal stem cells (MSCs), termed HAC-MSC that express 3 growth factors and 2 marker proteins including luciferase, and previously demonstrated that intrathecal administration of HAC-MSCs extended the lifespan in a mouse model of amyotrophic lateral sclerosis (ALS). However, donor cells disappeared rapidly after transplantation. To overcome this poo...
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