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#1De-Xiang Ban (Tianjin Medical University General Hospital)H-Index: 7
#2Xiaohong Kong (NKU: Nankai University)H-Index: 11
Last. Shi‐fu Guo (Tianjin Medical University General Hospital)H-Index: 2
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#1Mushfiquddin Khan (MUSC: Medical University of South Carolina)H-Index: 33
#2Pavan Kumar (MUSC: Medical University of South Carolina)
Last. Inderjit Singh (MUSC: Medical University of South Carolina)H-Index: 61
view all 8 authors...
Abstract The nitric oxide (NO) metabolome and the NO metabolite-based neurovascular protective pathways are dysregulated after stroke. The major NO metabolite S-nitrosoglutahione (GSNO) is essential for S-nitrosylation-based signaling events and the inhibition of S-nitrosoglutahione (GSNO)-metabolizing enzyme GSNO reductase (GSNOR) provides protective effects following cardiac ischemia. However, the role of GSNOR and GSNOR inhibition-mediated increased GSNO/S-nitrosylation is not understood in n...
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#1Ting Li (Capital Medical University)H-Index: 4
#2Xiaoxia Qu (Capital Medical University)H-Index: 1
Last. Junfang Xian (Capital Medical University)H-Index: 13
view all 10 authors...
Normal tension glaucoma (NTG) is a neurodegenerative disease involves multiple brain areas, but the mechanism remains unclear. The aim of this study is to investigate the correlation between structural injury and functional reorganization in the brain of NTG, using resting-state functional MRI and diffusion kurtosis imaging (DKI) data acquired for 26 NTG patients and 24 control subjects. Granger causality analysis (GCA) was used to calculate the effective connectivity (EC) between visual cortice...
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#1Alexander Hawlitschka (University of Rostock)H-Index: 8
#2Charlotte Berg (University of Rostock)
Last. Veronica Antipova (Medical University of Graz)
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In Parkinson's disease, dopamine depletion leads to hyperactivity of cholinergic interneurons in the caudate-putamen (CPu). Botulinum neurotoxin-A (BoNT-A) inhibits the release of acetylcholine in the peripheral nervous system and is also thought to act as a local anticholinergic drug when injected intrastriatally. In hemiparkinsonian (hemi-PD) rats, a unilateral intrastriatal injection of 1 ng BoNT-A significantly diminished apomorphine-induced rotation behavior for at least 3 months, the effec...
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#1Junichi Kitanaka (Hyogo College of Medicine)H-Index: 16
#2Nobue Kitanaka (Hyogo College of Medicine)H-Index: 16
Last. Rena Ozawa (Hyogo College of Medicine)
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Abstract A single administration with METH (3 mg/kg) induced a hyperlocomotion in male ICR mice. Pretreatment of mice with pitolisant, a histamine H3 receptor antagonist (5 and 10 mg/kg), for 30 min showed a significant reduction of the hyperlocomotion induced by METH, as compared with vehicle (saline)-pretreated subjects. Pretreatment of mice with the histamine H3 receptor antagonists JNJ-10181457 (5 and 10 mg/kg) or conessine (20 mg/kg), also showed similar inhibitory effects on METH-induced h...
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#1Jessica R. Barson (Drexel University)H-Index: 20
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#1Bo Liu (SHU: Shanghai University)H-Index: 1
Last. Jing-Shan ShiH-Index: 26
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The senescence-accelerated mouse prone 8 (SAMP8) mice have many pathological features of Alzheimer's disease (AD) with aging. We previously reported that Dendrobium nobile Lindl alkaloid (DNLA) effectively improved cognitive deficits in multiple Alzheimer's disease (AD) models. This study further used SAMP8 mice to study the anti-aging effects of DNLA, focusing on endoplasmic reticulum (ER) stress. DNLA and metformin were orally administered to SAMP8 mice starting at 4-month of age for 6 months....
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#1Robert J. Callister (University of Newcastle)H-Index: 24
#2Alan M. Brichta (University of Newcastle)H-Index: 21
Last. Douglas G. Stuart (UA: University of Arizona)H-Index: 43
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Abstract This article reviews the contributions of the English neurophysiologist, Charles Scott Sherrington [1857-1952], and his Australian PhD trainee and collaborator, John Carew Eccles [1903-1997], to the concept of central inhibition in the spinal cord and brain. Both were awarded Nobel Prizes; Sherrington in 1932 for “discoveries regarding the function of neurons,” and Eccles in 1963 for “discoveries concerning the ionic mechanisms involved in excitation and inhibition in central portions o...
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#1Irene MorgansternH-Index: 11
#2Gazal Gulati (Rockefeller University)
Last. Sarah F. Leibowitz (Rockefeller University)H-Index: 72
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Melanin-concentrating hormone (MCH) is a neuropeptide primarily transcribed in the lateral hypothalamus (LH), with vast projections to many areas throughout the central nervous system that play an important role in motivated behaviors and drug use. Anatomical, pharmacological and genetic studies implicate MCH in mediating the intake and reinforcement of commonly abused substances, acting by modulating several systems including the mesolimbic dopaminergic system, glutamatergic as well as GABAergi...
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